Evidence map›Paper›PMID 34968233›Full record

ArticleEpigenomes2019

Integrating Signals from Sperm Methylome Analysis and Genome-Wide Association Study for a Better Understanding of Male Fertility in Cattle.

Lingzhao Fang, Yang Zhou, Shuli Liu, Jicai Jiang, Derek M Bickhart, Daniel J Null, Bingjie Li, Steven G Schroeder, Benjamin D Rosen, John B Cole and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Emerging opportunities for DNA methylation biomarkers in cattle improvement.The Journal of reproduction and development · 2026
    Review
  3. Infertility and Auto-Antibodies: A Review.Antibodies (Basel, Switzerland) · 2025
    Review
  4. Search for Ancient Selection Traces in Faverolle Chicken Breed (Animals : an open access journal from MDPI · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023
    Review
  12. Article
  13. Article
  14. Emerging issues in genomic selection.Journal of animal science · 2021
    Article
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Lingzhao FangAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
Yang ZhouKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, Huazhong Agricultural University, Wuhan 430070, China.
Shuli LiuAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
Jicai JiangDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0001-6890-7539
Derek M BickhartDairy Forage Research Center, Agricultural Research Service, USDA, Madison, WI 53718, USA.ORCID 0000-0003-2223-9285
Daniel J NullAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
Bingjie LiAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
Steven G SchroederAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
Benjamin D RosenAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.ORCID 0000-0001-9395-8346
John B ColeAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.ORCID 0000-0003-1242-4401
Curtis P Van TassellAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.ORCID 0000-0002-8416-2087
Li MaDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.
George E LiuAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.ORCID 0000-0003-0192-6705
Agricultural Research Service · USUniversity of Maryland, College Park · USHuazhong Agricultural University · CN

Funding

National Institute of Food and Agriculture 2013-67015-20951National Institute of Food and Agriculture 2016-67015-24886National Institute of Food and Agriculture 2019-67015-29321United States - Israel Binational Agricultural Research and Development Fund US-4997-17
6 · The paper itself

Abstract

Decreased male fertility is a big concern in both human society and the livestock industry. Sperm DNA methylation is commonly believed to be associated with male fertility. However, due to the lack of accurate male fertility records (i.e., limited mating times), few studies have investigated the comprehensive impacts of sperm DNA methylation on male fertility in mammals. In this study, we generated 10 sperm DNA methylomes and performed a preliminary correlation analysis between signals from sperm DNA methylation and signals from large-scale (

Indexed as

cattle complex traitslarge-scale GWASmale fertilitysperm DNA methylation

Identifiers

PMID34968233
PMCPMC8594688
OpenAlexW2945032367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.