Evidence map›Paper›PMID 34968231›Full record

ArticleEpigenomes2019

Global DNA Methylation in the Limbic System of Cattle.

Bonnie Cantrell, Hannah Lachance, Brenda Murdoch, Julia Sjoquist, Richard Funston, Robert Weaber, Stephanie McKay

Open access · diamondAbstract read
In one paragraph

Article in Epigenomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
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  4. Examining the extent of environmental contributions toward DNA methylation and phenotypic variation.Animal frontiers : the review magazine of animal agriculture · 2021
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bonnie CantrellDepartment of Animal and Veterinary Sciences, University of Vermont, Burlington, VT 05405, USA.
Hannah LachanceDepartment of Animal and Veterinary Sciences, University of Vermont, Burlington, VT 05405, USA.
Brenda MurdochDepartment of Animal and Veterinary Science, University of Idaho, Moscow, ID 83844, USA.
Julia SjoquistDepartment of Neurological Sciences, University of Vermont, Burlington, VT 05405, USA.
Richard FunstonWest Central Research and Extension Center, University of Nebraska, North Platte, NE 69101, USA.
Robert WeaberDepartment of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.
Stephanie McKayDepartment of Animal and Veterinary Sciences, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-1434-3111
University of Vermont · USKansas State University · USUniversity of Idaho · US

Funding

U.S. Department of Agriculture 2013-VT-H02017MSU.S. Department of Agriculture 2016-67016-24766
6 · The paper itself

Abstract

To elucidate the extent to which DNA methylation varies across multiple tissues in the brain and between animals, we have quantified global DNA methylation in tissues comprising the limbic system for six Red Angus x Simmental steers. Global DNA methylation was measured in nine regions of the bovine brain: amygdala, the bed nucleus of the stria terminalis, cingulate gyrus, dorsal raphe, hippocampus, hypothalamus, nucleus accumbens, periaqueductal gray and prefrontal cortex. DNA methylation varies among animals for each tissue type and varies among tissue types for each animal. The highest amounts of DNA methylation were found in the amygdala, cingulate gyrus and dorsal raphe, while the bed nucleus of the stria terminalis, nucleus accumbens and periaqueductal gray had the lowest amounts of DNA methylation. A heatmap sorted by

Indexed as

braincattleepigeneticsmethylationtemperament

Identifiers

PMID34968231
PMCPMC8594672
OpenAlexW2943147315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.