Evidence map›Paper›PMID 34968159›Full record

ArticleNeurorehabilitation and neural repair2022

Functional Connectivity and Speech Entrainment Speech Entrainment Improves Connectivity Between Anterior and Posterior Cortical Speech Areas in Non-fluent Aphasia.

Lisa Johnson, Grigori Yourganov, Alexandra Basilakos, Roger David Newman-Norlund, Helga Thors, Lynsey Keator, Chris Rorden, Leonardo Bonilha, Julius Fridriksson

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Article in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lisa JohnsonDepartment of Communication Sciences and Disorders, 2629University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-8727-7269
Grigori YourganovCyberinfrastructure and Technology Integration, 2545Clemson University, Clemson, SC, USA.
Alexandra BasilakosDepartment of Communication Sciences and Disorders, 2629University of South Carolina, Columbia, SC, USA.ORCID 0000-0003-0053-1082
Roger David Newman-NorlundDepartment of Psychology, 2629University of South Carolina, Columbia, SC, USA.
Helga Thors37557Landspitali University Hospital, Iceland.
Lynsey KeatorDepartment of Communication Sciences and Disorders, 2629University of South Carolina, Columbia, SC, USA.
Chris RordenDepartment of Psychology, 2629University of South Carolina, Columbia, SC, USA.
Leonardo BonilhaDepartment of Neurology, 2345Medical University of South Carolina, Charleston, SC, USA.
Julius FridrikssonDepartment of Communication Sciences and Disorders, 2629University of South Carolina, Columbia, SC, USA.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Speech Entrainment Treatment for Broca's AphasiaR21DC014170 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2015 to 2016
$403k
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R21 DC014170
6 · The paper itself

Abstract

backgroundSpeech entrainment (SE), the online mimicking of an audio-visual speech model, has been shown to increase speech fluency in individuals with non-fluent aphasia. One theory that may explain why SE improves speech output is that it synchronizes functional connectivity between anterior and posterior language regions to be more similar to that of neurotypical speakers.

objectivesThe present study tested this by measuring functional connectivity between 2 regions shown to be necessary for speech production, and their right hemisphere homologues, in 24 persons with aphasia compared to 20 controls during both free (spontaneous) speech and SE.

methodsRegional functional connectivity in participants with aphasia were normalized to the control data. Two analyses were then carried out: (1) normalized functional connectivity was compared between persons with aphasia and controls during free speech and SE and (2) stepwise linear models with leave-one-out cross-validation including normed functional connectivity during both tasks and proportion damage to the left hemisphere as independent variables were created for each language score.

resultsLeft anterior-posterior functional connectivity and left posterior to right anterior functional connectivity were significantly more similar to connectivity of the control group during SE compared to free speech. Additionally, connectivity during free speech was more associated with language measures than connectivity during SE.

conclusionsOverall, these results suggest that SE promotes normalization of functional connectivity (i.e., return to patterns observed in neurotypical controls), which may explain why individuals with non-fluent aphasia produce more fluent speech during SE compared to spontaneous speech.

Indexed as

ConnectomeImitative BehaviorMouthSpeech TherapyStroke RehabilitationAdultAgedAphasia, BrocaChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOutcome Assessment, Health CareSpeech Perceptionaphasiaaphasia recoverychronic strokefunctional connectivityspeech entrainment

Identifiers

PMID34968159
PMCPMC8982955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.