ArticleMolecular nutrition & food research2022
Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy.
Article in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Purslane (Portulaca oleracea L.) Extract Alleviates Atherosclerosis in ApoEMolecular nutrition & food research · 2026Article
- Optimization extraction of Allium mongolicum Regel polysaccharide and alleviation of intestinal injury via inhibition of the PERK/ATF4/CHOP signaling pathway.Frontiers in veterinary science · 2026Article
- A Review and Survey of Local Eastern Kentucky Medicinal Plants and Their Pharmacological Benefits.Plants (Basel, Switzerland) · 2025Review
- Modulation of Endoplasmic Reticulum Stress by Selected Polyphenols fromPlants (Basel, Switzerland) · 2025Review
- Phytochemical Composition, Bioactive Compounds, and Antidiabetic Potential of Four Medicinal Plants Native to the UAE:Biology · 2025Review
- Establishment and Characterization of Behavioral Changes in the Nuclear Localization Human α-Synuclein Transgenic Mice.Diseases (Basel, Switzerland) · 2025Article
- Review
- Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis.World journal of clinical cases · 2024Article
- Review
- Protective Effects of Different Molecular Weights of Purslane (Antioxidants (Basel, Switzerland) · 2023Article
- Effect of Purslane (International journal of molecular sciences · 2023Article
- Phytochemical Characteristics and Anti-Inflammatory, Immunoregulatory, and Antioxidant Effects ofEvidence-based complementary and alternative medicine : eCAM · 2023Review
- Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis.Frontiers in pharmacology · 2023Review
- Article
- The Synergetic Effect of EgyptianAntioxidants (Basel, Switzerland) · 2022Article
- Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy.Molecular nutrition & food research · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
scopeTo investigate the role of endoplasmic reticulum stress (ERS)-induced autophagy in inflammatory bowel disease (IBD) and the intervention mechanism of Portulaca oleracea L. (POL) extract, a medicinal herb with anti-inflammatory, antioxidant, immune-regulating, and antitumor properties, in vitro and in vivo. METHODS AND
resultsAn IL-10-deficient mouse model is used for in vivo experiments; a thapsigargin (Tg)-stimulated ERS model of human colonic mucosal epithelial cells (HIECs) is used for in vitro experiments. The levels of ERS-autophagy-related proteins are examined by immunofluorescence and Western blot. Cellular ultrastructure is assessed with transmission electron microscopy. POL extract promotes a healing effect on colitis by regulating ERS-autophagy through the protein kinase R-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2α (eIF2α)/Beclin1-microtubule-associated protein light chain 3II (LC3II) pathway.
conclusionOverall, the results of this study further confirm the anti-inflammatory mechanism and protective effect of POL extract and provide a new research avenue for the clinical treatment of IBD.
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