Evidence map›Paper›PMID 34967562›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2021

The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers.

Yesim Ozdemir, Murat Cag, Emel Colak, Nuriye Coskun, Neslihan Basgoz, Hakan Sarici, Dilek Kaan, Muhammet Dogan, Kemal Deniz, Mevlude Inanc and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yesim OzdemirUskudar University, Medical Faculty, Medical Genetics Department, Umraniye, 34768 Istanbul, Turkey.ORCID 0000000243982767
Murat CagUniversité de Strasbourg, Service de chirurgie vasculaire et de transplantation, Nouvel Hôpital Civil, Université de Strasbourg 1 Place de l'Hôpital 67000 Strasbourg, France.ORCID 0000000340064079
Emel ColakErciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey.ORCID 0000000240407855
Nuriye CoskunErciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey.ORCID 0000000178145224
Neslihan BasgozErciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey.ORCID 0000000335675721
Hakan SariciYozgat City Hospital,66100, Yozgat, Turkey.ORCID 0000000214685288
Dilek KaanBetul- Ziya Eren Genome and Stem Cell Center, 38280, Kayseri, Turkey.ORCID 0000000336222249
Muhammet DoganErciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey.ORCID 0000000250347083
Kemal DenizErciyes University, Medical Faculty, Pathology Department, 38280, Kayseri, Turkey.ORCID 0000000177492152
Mevlude InancErciyes University, Medical Faculty, Oncology Department,38280, Kayseri, Turkey.ORCID 0000000237373420
Yusuf OzkulErciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey.
Üsküdar University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIt is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers.

methodsA total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencing method. The effect of gene mutations on metastasis and overall survival were evaluated.

resultsThe mean age of patients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was 56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis date was 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher rate in metastatic colon cancer (p<0.05).

conclusionWe showed that APC, MUTYH, and TP53 mutations are associated with distant organ metastasis.

Indexed as

AdolescentAdultAgedCase-Control StudiesColonic NeoplasmsDNA GlycosylasesFemaleGenes, APCGenes, p53Genetic Predisposition to DiseaseGerm-Line MutationHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationDNA GlycosylasesmutY adenine glycosylaseColon cancerGene MutuationMetastasis

Identifiers

PMID34967562
PMCPMC9080374
OpenAlexW4200449322

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.