ArticleBrain and behavior2022
Altered brain activity in end-stage knee osteoarthritis revealed by resting-state functional magnetic resonance imaging.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis.Scientific reports · 2023Pooled it
- Effects of Acupuncture-Combined Tuina on Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Electroacupuncture alleviates pain after total knee arthroplasty through regulating neuroplasticity: A resting-state functional magnetic resonance imaging study.Brain and behavior · 2023Trial
- Altered activation patterns of sensorimotor cortex during level walking and stair climbing in patients with knee osteoarthritis: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis.Journal of medical biochemistry · 2025Article
- Differences in sensory-motor cortex activation patterns during level and stair walking in patients with knee osteoarthritis: protocol for a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Cerebral Mechanism of Tuina on the Descending Pain Inhibitory System in Knee Osteoarthritis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Altered Brain Functional and Effective Connectivity Induced by Electroacupuncture in Rats Following Anterior Cruciate Ligament Transection.Journal of pain research · 2024Article
- Altered activation patterns of the sensory-motor cortex in patients with knee osteoarthritis during knee isokinetic movement at different speeds.Frontiers in bioengineering and biotechnology · 2024Article
- Structural and functional brain changes in people with knee osteoarthritis: a scoping review.PeerJ · 2023Article
- Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects.Diagnostics (Basel, Switzerland) · 2022Review
- Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Altered brain activity in end-stage knee osteoarthritis revealed by resting-state functional magnetic resonance imaging.Brain and behavior · 2022Article
- Reduction of Interhemispheric Homotopic Connectivity in Cognitive and Visual Information Processing Pathways in Patients With Thyroid-Associated Ophthalmopathy.Frontiers in human neuroscience · 2022Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionKnee osteoarthritis (KOA) is characterized by a degenerative change of knee cartilage and secondary bone hyperplasia, resulting in pain, stiffness, and abnormal walking gait. Long-term chronic pain causes considerable cortical plasticity alternations in patients. However, the brain structural and functional alterations associated with the pathological changes in knee joints of end-stage KOA patients remain unclear. This study aimed to analyze the structural and functional connectivity alterations in end-stage KOA to comprehensively understand the main brain-associated mechanisms underlying its development and progression.
methodsIn this study, 37 patients with KOA and 37 demographically matched healthy controls (HCs) were enrolled. Alternations in gray matter (GM) volume in patients with KOA were determined using voxel-based morphometry. The region with the largest GM volume alteration was selected as the region of interest to calculate the voxel-wise resting-state functional connectivity (rs-FC) in the two groups. Pearson's correlation coefficient was used to analyze the correlation between clinical measures and GM volume alternations in patients with KOA.
resultsCompared with HCs, patients with KOAs exhibited significantly decreased GM volumes in the left middle temporal gyrus (left-MTG) and the left inferior temporal gyrus. Results of the voxel-wise rs-FC analysis revealed that compared with HCs, patients with KOA had decreased left-MTG rs-FC to the right dorsolateral superior frontal gyrus, left middle frontal gyrus, and left medial superior frontal gyrus. GM volume in the left-MTG was negatively correlated with the Western Ontario and McMaster Universities Arthritis Index in patients with KOA (r = -0.393, p = .016).
conclusionStructural remodeling and functional connectivity alterations may be one of the central brain mechanisms associated with end-stage KOA.
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