Evidence map›Paper›PMID 34967098›Full record

ArticleJournal of separation science2022

A convenient separation strategy for fungal anthraquinones by centrifugal partition chromatography.

Fabian Hammerle, Michael Zwerger, Anja Höck, Markus Ganzera, Ursula Peintner, Bianka Siewert

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of separation science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fabian HammerleInstitute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, Innsbruck, Tyrol, 6020, Austria.ORCID https://orcid.org/0000-0002-4553-823X
Michael ZwergerInstitute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, Innsbruck, Tyrol, 6020, Austria.ORCID https://orcid.org/0000-0002-0245-6146
Anja HöckInstitute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, Innsbruck, Tyrol, 6020, Austria.
Markus GanzeraInstitute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, Innsbruck, Tyrol, 6020, Austria.ORCID https://orcid.org/0000-0002-7407-9060
Ursula PeintnerInstitute of Microbiology, University of Innsbruck, Technikerstraße 25, Innsbruck, Tyrol, 6020, Austria.ORCID https://orcid.org/0000-0001-5388-4266
Bianka SiewertInstitute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, Innsbruck, Tyrol, 6020, Austria.ORCID https://orcid.org/0000-0002-4910-1756
Universität Innsbruck · AT

Funding

Austrian Science Fund FWF P 31915
6 · The paper itself

Abstract

As recently shown, some fungal pigments exhibit significant photoactivity turning them into promising agents for the photodynamic treatment of microbial infections or malignant diseases. In the present study, a separation strategy for fungal anthraquinones was developed based on centrifugal partition chromatography. A suitable method was explored employing a methanolic extract of the fruiting bodies of Cortinarius sanguineus (Agaricales, Basidiomycota). An excellent fractionation was achieved using a biphasic solvent system comprising chloroform/ethyl acetate/methanol/water/acetic acid (3:1:3:2:1, v/v/v/v/v) operating in ascending mode. Experiments on an analytical scale with extracts of closely related Cortinarius species exhibited broad applicability of the devised system. Up to six pigments could be purified directly from the crude extract. Preparative-scale fractionation of the methanol extracts of C. malicorius and C. sanguineus demonstrated that up-scaling was possible without compromising selectivity.

Indexed as

AnthraquinonesPlant ExtractsChromatography, LiquidMethanolSolventsAnthraquinonesMethanolPlant ExtractsSolventsanthraquinone glycosidesanthraquinonesbasidiomycetescentrifugal partition chromatographycortinarius fruiting bodies

Identifiers

PMID34967098
PMCPMC9415121
OpenAlexW4200126105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.