Evidence map›Paper›PMID 34966906›Full record

ArticleFrontiers in dental medicine2021

Single-Cell Transcriptomic Analysis Reveals Developmental Relationships and Specific Markers of Mouse Periodontium Cellular Subsets.

Mizuki Nagata, Angel Ka Yan Chu, Noriaki Ono, Joshua D Welch, Wanida Ono

Open access · goldAbstract read
In one paragraph

Article in Frontiers in dental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

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  11. Control of alveolar bone development, homeostasis, and socket healing by salt-inducible kinases.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mizuki NagataDepartment of Orthodontics, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, United States.
Angel Ka Yan ChuDepartment of Computational Medicine and Bioinformatics, Department of Computer Science and Engineering, University of Michigan, Ann Arbor, MI, United States.
Noriaki OnoDepartment of Diagnostic & Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, United States.
Joshua D WelchDepartment of Computational Medicine and Bioinformatics, Department of Computer Science and Engineering, University of Michigan, Ann Arbor, MI, United States.
Wanida OnoDepartment of Orthodontics, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, United States.
The University of Texas Health Science Center at Houston · USUniversity of Michigan–Ann Arbor · US

Funding

Quantitative definition of cell identity from single-cell multi-omic, spatial, and perturbation dataR01HG010883 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joshua Welch · 2019 to 2026
$4.4M
Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their nichesR01DE030630 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI, ONO, WANIDA · 2021 to 2025
$2.2M
Dynamics and Regulations of Bone Stem Cells in VivoR01DE026666 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI · 2018 to 2022
$2.1M
Dental Follicle: A Central Regulator of Tooth Root Formation and RegenerationR01DE029181 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, WANIDA · 2021 to 2025
$1.9M
NHGRI NIH HHS R01 HG010883NIDCR NIH HHS R01 DE026666NIDCR NIH HHS R01 DE029181NIDCR NIH HHS R01 DE030630
6 · The paper itself

Abstract

The periodontium is essential for supporting the functionality of the tooth, composed of diversity of mineralized and non-mineralized tissues such as the cementum, the periodontal ligament (PDL) and the alveolar bone. The periodontium is developmentally derived from the dental follicle (DF), a fibrous tissue surrounding the developing tooth bud. We previously showed through

Indexed as

dental folliclemesenchymal progenitor cellsmouse genetic modelsparathyroid hormone-related proteinperiodontiumsingle cell analysis

Identifiers

PMID34966906
PMCPMC8713353
OpenAlexW3189043318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.