ArticleThe Lancet. Rheumatology2020
Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in The Lancet. Rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02161406 (A Phase 2 Study to Evaluate Subcutaneous Abatacept vs. Placebo in Diffuse Cutaneous Systemic Sclerosis- a Double-blind, Placebo-controlled, Randomized Controlled Trial.), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 2 Study to Evaluate Subcutaneous Abatacept vs. Placebo in Diffuse Cutaneous Systemic Sclerosis- a Double-blind, Placebo-controlled, Randomized Controlled Trial.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Efficacy of different pharmacological therapies for diffuse cutaneous systemic sclerosis: a systematic review and network meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- An update on targeted therapies in systemic sclerosis based on a systematic review from the last 3 years.Arthritis research & therapy · 2021Pooled it
- Machine-learning classification identifies patients with early systemic sclerosis as abatacept responders via CD28 pathway modulation.JCI insight · 2022Trial
- Review
- Systematic Review and Model-Based Meta-Analysis of Targeted Drugs for Systemic Sclerosis.Pharmaceutics · 2026Review
- The immune landscape of systemic sclerosis: from pathogenic mechanisms to precision therapeutic breakthroughs.Frontiers in immunology · 2026Review
- [S2k guidelines on diagnostics and treatment of systemic sclerosis : Full version].Zeitschrift fur Rheumatologie · 2025Review
- Racial and ethnic representation in systemic sclerosis clinical trials: a 25-year analysis of ClinicalTrials.gov (1999-2025).EULAR rheumatology open · 2025Article
- An international perspective on the future of systemic sclerosis research.Nature reviews. Rheumatology · 2025Review
- Emerging therapeutic targets in systemic sclerosis.Journal of molecular medicine (Berlin, Germany) · 2024Review
- Immunotherapy Strategy for Systemic Autoimmune Diseases: Betting on CAR-T Cells and Antibodies.Antibodies (Basel, Switzerland) · 2024Review
- Novel and potential future therapeutic options in systemic autoimmune diseases.Frontiers in immunology · 2024Review
- Experiences of Exergaming for Upper Extremity Exercises in People With Systemic Sclerosis.OTJR : occupation, participation and health · 2023Article
- Novel Therapeutic Strategies in the Treatment of Systemic Sclerosis.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies.Clinical reviews in allergy & immunology · 2023Review
- State-of-the-art evidence in the treatment of systemic sclerosis.Nature reviews. Rheumatology · 2023Review
- New Era in Systemic Sclerosis Treatment: Recently Approved Therapeutics.Journal of clinical medicine · 2022Review
- Emerging Evidence and Treatment Perspectives from Randomized Clinical Trials in Systemic Sclerosis: Focus on Interstitial Lung Disease.Biomedicines · 2022Review
- Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches.Biomedicines · 2022Review
- Co-Inhibitory Molecules - Their Role in Health and Autoimmunity; Highlighted by Immune Related Adverse Events.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 14 institutions in 6 countries.
Lorinda ChungStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Cathie SpinoStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Richard McLainStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Sindhu R JohnsonStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Christopher P DentonStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Jerry A MolitorStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Virginia D SteenStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Robert LafyatisStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Robert W SimmsStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Suzanne KafajaStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Tracy M FrechStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Vivien HsuStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Robyn T DomsicStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Janet E PopeStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Jessica K GordonStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Maureen D MayesStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Nora SandorfiStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Faye N HantStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Elana J BernsteinStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Soumya ChatterjeeStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Flavia V CastelinoStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Ali AjamStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Yannick AllanoreStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Marco Matucci-CerinicStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Michael L WhitfieldStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Oliver DistlerStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Ora SingerStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Amber YoungStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Vivek NagarajaStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
David A FoxStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Daniel E FurstStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Dinesh KhannaStanford University School of Medicine, Stanford, CA, USA (Prof L Chung MD); Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA (Prof C Spino ScD, R McLain MS); Division of Rheumatology, Mount Sinai Hospital and University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada (S R Johnson MD); University College London, Division of Medicine, London, UK (Prof C P Denton MD); Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, USA (J A Molitor MD); Rheumatology, Georgetown University Medical Center, Washington, DC, USA (ProfV D Steen MD); Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, USA (Prof R Lafyatis MD); Rheumatology, Boston University School of Medicine, Boston, MA, USA (Prof R W Simms MD); Rheumatology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA (Prof R W Simms); Department of Internal Medicine, University of Californiaat Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA (S Kafaja MD, Prof D E Furst MD); Division of Rheumatology, University of Utah, Salt Lake City, UT, USA (T M Frech MD); Rutgers-Robert Wood Johnson Medical School, Department of Medicine, Rheumatology Division, New Brunswick, NJ, USA (VHsu MD); Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA (R T Domsic MD); Department of Medicine, University of Western Ontario, London, ON, Canada (Prof J E Pope MD); Rheumatology, Hospital for Special Surgery, NewYork, NY, USA (J K Gordon MD); McGovern Medical School, University of Texas, Houston, TX, USA (Prof MD Mayes MD); Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, USA (N Sandorfi MD); Medicine-Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA (F N Hant DO); Rheumatology, Columbia University, New York, NY, USA (E J Bernstein MD); Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA (S Chatterjee MD); Rheumatology, Harvard Medical School, Boston, MA, USA (F V Castelino MD); Division of Rheumatology-Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA (A Ajam MBBS); Paris Descartes University, Institut National de la Santé et de la Recherche Médicale U1016, Université Sorbonne Paris Cité, and Cochin Hospital, Paris, France (Prof Y Allanore MD); Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology Azienda Ospedaliero Universitaria Careggi, Florence, Italy (Prof M Matucci-Cerinic MD); Geisel School of Medicine at Dartmouth, Hanover, NH, USA (Prof M L Whitfield PhD); Department of Rheumatology, University Hospital, Zurich, Switzerland (Prof O Distler MD); and Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, USA (O Singer MD, A Young MD, V Nagaraja MD, Prof D A Fox MD, Prof D Khanna MD).
Georgetown University · USMount Sinai Hospital · CAUniversity College London · GBUniversity of Michigan–Ann Arbor · USColumbia University · USDartmouth College · USDélégation Paris 5 · FRGeorgetown University Medical Center · USJohnson University · USScleroderma Foundation · USThe University of Texas Health Science Center at Houston · USUniversity Hospital of Zurich · CHUniversity Medical Center · USUniversity of Florence · IT
Funding
Outcomes Research in Rheumatic DiseasesK24AR063120 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHANNA, DINESH · 2012 to 2022
$1.6MSystemic Sclerosis-Associated Interstitial Lung Disease Response IndexR01AR070470 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHANNA, DINESH · 2017 to 2019
$642kUniversity of Michigan Autoimmunity Center of Excellence, Clinical Research ProgrUM1AI110557 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOX, DAVID ALAN · 2014 to 2018
$543kNIAID NIH HHS UM1 AI110557NIAMS NIH HHS K24 AR063120NIAMS NIH HHS R01 AR070470
Abstract
backgroundAbatacept was well tolerated by patients with early diffuse cutaneous systemic sclerosis in a phase 2, double-blind randomised trial, with potential efficacy at 12 months. We report here the results of an open-label extension for 6 months.
methodsPatients (aged ≥18 years) with diffuse cutaneous systemic sclerosis of less than 3 years' duration from their first non-Raynaud's symptom were enrolled into the ASSET trial (A Study of Subcutaneous Abatacept to Treat DiffuseCutaneous Systemic Sclerosis), which is a double-blind trial at 22 sites in Canada, the UK, and the USA. Aftercompletion of 12 months of treatment with either abatacept or placebo, patients received a further 6 months ofabatacept (125 mg subcutaneous every week) in an open-label extension. The primary endpoint of the double-blind trial was modified Rodnan Skin Score (mRSS) at 12 months, which was reassessed at 18 months in the open-label extension. The primary analysis included all participants who completed the double-blind trial and received at least one dose of open-label treatment (modified intention to treat). This trial is registered with ClinicalTrials.gov, NCT02161406.
findingsBetween Sept 22, 2014, and March 15, 2017, 88 participants were randomly allocated in the double-blind trial either abatacept (n=44) or placebo (44); 32 patients from each treatment group completed the 6-month open-labelextension. Among patients assigned abatacept, a mean improvement from baseline in mRSS was noted at 12 months (-6·6 [SD 6·4]), with further improvement seen during the open-label extension period (-9·8 [8·1] at month 18). Participants assigned placebo had a mean improvement from baseline in mRSS at 12 months (-3·7 [SD 7·6]), with a further improvement at month 18 (-6·3 [9·3]). Infections during the open-label extension phase occurred in nine patients in the placebo-abatacept group (12 adverse events, one serious adverse event) and in 11 patients in theabatacept-abatacept group (14 adverse events, one serious adverse event). Two deaths occurred during the 12-month double-blind period in the abatacept group, which were related to scleroderma renal crisis; no deaths were recorded during the open-label extension.
interpretationDuring the 6-month open-label extension, no new safety signals for abatacept were identified in the treatment of diffuse cutaneous systemic sclerosis. Clinically meaningful improvements in mRSS and other outcome measures were observed in both the abatacept and placebo groups when patients transitioned to open-label treatment. These data support further studies of abatacept in diffuse cutaneous systemic sclerosis.
fundingBristol-Myers Squibb and National Institutes of Health.
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Registered trials
NCT02161406ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.