Evidence map›Paper›PMID 34966837›Full record

ArticleTransplantation direct2022

Predictive Factors for Humoral Response After 2-dose SARS-CoV-2 Vaccine in Solid Organ Transplant Patients.

Olivier Marion, Arnaud Del Bello, Florence Abravanel, Stanislas Faguer, Laure Esposito, Anne Laure Hebral, Julie Bellière, Jacques Izopet, Nassim Kamar

Abstract read
In one paragraph

Article in Transplantation direct, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. Torque teno virus DNA load as a predictive marker of antibody response to a three-dose regimen of COVID-19 mRNA-based vaccine in lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  17. COVID-19 Vaccination in Lung Transplant Recipients.Indian journal of thoracic and cardiovascular surgery · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Olivier MarionDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.
Arnaud Del BelloDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.
Florence AbravanelINFINITY - INSERM U1291-CNRS U5051, Toulouse, France.
Stanislas FaguerDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.
Laure EspositoDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.
Anne Laure HebralDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.
Julie BellièreDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.
Jacques IzopetINFINITY - INSERM U1291-CNRS U5051, Toulouse, France.
Nassim KamarDepartment of Nephrology and Organ Transplantation, Toulouse Rangueil University Hospital, Toulouse, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA weak immunogenicity has been reported in solid organ transplant (SOT) recipients after 2 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. The aim of this retrospective study was to identify the predictive factors for humoral response in SOT patients.

methodsThree hundred and ninety-three SOT patients from our center with at least 4 wk of follow-up after 2 doses of mRNA-based vaccine were included in this study. Anti-SARS-Cov-2 spike protein antibodies were assessed before and after vaccination.

resultsAnti-SARS-CoV-2 antibodies were detected in 34% of the patients: 33.7% of kidney transplant patients, 47.7% of liver transplant patients, and 14.3% of thoracic transplant patients (

conclusionsThe immunosuppressive regimen is a modifiable predictive factor for humoral response to SARS-CoV-2 vaccine.

Identifiers

PMID34966837
PMCPMC8710345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.