Evidence map›Paper›PMID 34966835›Full record

ArticleInnovative surgical sciences2021

Prospective surgical solutions in degenerative spine: spinal simulation for optimal choice of implant and targeted device development.

Monique Salchow-Gille, Bernhard Rieger, Clemens Reinshagen, Marek Molcanyi, Joschka Lemke, Uta Brautferger, Kerim Hakan Sitoci-Ficici, Witold Polanski, Thomas Pinzer, Gabriele Schackert

Open access · goldAbstract read
In one paragraph

Article in Innovative surgical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Monique Salchow-GilleShort Care Clinic, Greifswald, Germany.
Bernhard RiegerShort Care Clinic, Greifswald, Germany.
Clemens ReinshagenDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marek MolcanyiInstitute of Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Joschka LemkeKlinikum Herford, Spine Surgery, Herford, Germany.
Uta BrautfergerDepartment of Urology, University Hospital of Rostock, Rostock, Germany.
Kerim Hakan Sitoci-FiciciDepartment of Neurosurgery, University Hospital of Dresden, Dresden, Germany.
Witold PolanskiDepartment of Neurosurgery, University Hospital of Dresden, Dresden, Germany.
Thomas PinzerDepartment of Neurosurgery, University Hospital of Dresden, Dresden, Germany.
Gabriele SchackertDepartment of Neurosurgery, University Hospital of Dresden, Dresden, Germany.
Universitätsmedizin Greifswald · DEHarvard University · USHerford Hospital · DEMedical University of Graz · ATUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe most important goal of surgical treatment for spinal degeneration, in addition to eliminating the underlying pathology, is to preserve the biomechanically relevant structures. If degeneration destroys biomechanics, the single segment must either be surgically stabilized or functionally replaced by prosthetic restoration. This study examines how software-based presurgical simulation affects device selection and device development.

methodsBased on videofluoroscopic motion recordings and pixel-precise processing of the segmental motion patterns, a software-based surrogate functional model was validated. It characterizes the individual movement of spinal segments relative to corresponding cervical or lumbar spine sections. The single segment-based motion of cervical or lumbar spine of individual patients can be simulated, if size-calibrated functional X-rays of the relevant spine section are available. The software plug-in "biokinemetric triangle" has been then integrated into this software to perform comparative segmental motion analyses before and after treatment in two cervical device studies: the correlation of implant-induced changes in the movement geometry and patient-related outcome was examined to investigate, whether this surrogate model could provide a guideline for implant selection and future implant development.

resultsFor its validation in 253 randomly selected patients requiring single-level cervical (n=122) or lumbar (n=131) implant-supported restoration, the biokinemetric triangle provided significant pattern recognition in comparable investigations (p<0.05) and the software detected device-specific changes after implant-treatment (p<0.01). Subsequently, 104 patients, who underwent cervical discectomy, showed a correlation of the neck disability index with implant-specific changes in their segmental movement geometry: the preoperative simulation supported the best choice of surgical implants, since the best outcome resulted from restricting the extent of the movement of adjacent segments influenced by the technical mechanism of the respective device (p<0.05).

conclusionsThe implant restoration resulted in best outcome which modified intersegmental communication in a way that the segments adjacent to the implanted segment undergo less change in their own movement geometry. Based on our software-surrogate, individualized devices could be created that slow down further degeneration of adjacent segments by influencing the intersegmental communication of the motion segments.

Indexed as

biokinemetriecagediscectomyfunctional replacementfusionminimally invasive spine surgeryprosthesisrange of motionsimulation

Identifiers

PMID34966835
PMCPMC8668033
OpenAlexW3153769292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.