Evidence map›Paper›PMID 34966718›Full record

ArticleFrontiers in chemistry2021

Vitamin E Acetate Determination in Vaping Liquids and Non-targeted Analysis of Vaping Emissions of Diluents of Concern, Vitamin E Acetate and Medium-Chain Triglycerides Oil.

Ivana Kosarac, Cariton Kubwabo, Guru Prasad Katuri, Dora Petraccone, Trevor K Mischki

Abstract read
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trends in e-cigarette use in Canada from 2015 to 2021: findings from the nationally representative surveys.Canadian journal of public health = Revue canadienne de sante publique · 2026
    Article
  2. Cannabis concentrate vaping chemistry.Frontiers in toxicology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ivana KosaracOffice of Research and Surveillance, Tobacco Control Directorate, Controlled Substances and Cannabis Branch, Health Canada, Ottawa, ON, Canada.
Cariton KubwaboExposure and Biomonitoring Division, Environmental and Radiation Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada.
Guru Prasad KaturiExposure and Biomonitoring Division, Environmental and Radiation Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada.
Dora PetracconeOffice of Research and Surveillance, Tobacco Control Directorate, Controlled Substances and Cannabis Branch, Health Canada, Ottawa, ON, Canada.
Trevor K MischkiOffice of Research and Surveillance, Tobacco Control Directorate, Controlled Substances and Cannabis Branch, Health Canada, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the summer of 2019, cases of lung injury associated with vaping emerged in North America, including among individuals who reported exclusive use of nicotine vaping liquids. Once vitamin E acetate was identified as a potential causative agent a quantitative method based on a simple sample dilution, separation by gas chromatography and analysis by triple quadrupole mass spectrometry (GC MSMS) was developed. Method detection limit (MDL) and limit of quantification (LOQ) were determined at 0.159 µg/mL and 0.505 µg/mL, respectively. The analysis was performed on a subset of 203 commercially sourced nicotine containing vaping liquids of various flavour profile and nicotine range (nicotine free-59 mg/mL) from an internal inventory. The target analyte, Vitamin E Acetate, was not detected in any samples analyzed, as expected, given the reported detection in literature and high association of the chemical with cannabis and not nicotine containing vaping products.

Indexed as

aerosolcannabisemissiongc msmedium chain triglyceridesnicotinevapingvitamin E acetate

Identifiers

PMID34966718
PMCPMC8710514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.