ArticleJournal of clinical and translational hepatology2021
Prognostic Nomogram for Patients with Hepatitis E Virus-related Acute Liver Failure: A Multicenter Study in China.
Article in Journal of clinical and translational hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- [Global differences and challenges in the definition of acute liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- The Gut Microbiota in Elderly Patients with Acute Hepatitis E Infection.Journal of clinical and translational hepatology · 2025Article
- The gamma-glutamyl transpeptidase to platelet ratio: a good noninvasive biomarker for predicting for the occurrence and prognosis of patients with hepatitis E virus-related acute liver failure.Frontiers in medicine · 2025Article
- Realm of hepatitis E: Challenges and opportunities.World journal of experimental medicine · 2024Article
- Viral hepatitis-induced acute liver failure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- The impact of COVID-19 on liver injury in various age.World journal of virology · 2023Review
- Prognostic Scores in Acute Liver Failure Due to Viral Hepatitis.Diagnostics (Basel, Switzerland) · 2023Review
- Increase in Serum Soluble Tim-3 Level Is Related to the Progression of Diseases After Hepatitis Virus Infection.Frontiers in medicine · 2022Article
- Editorial: Diagnosis, Treatment, and Prognosis of Viral Hepatitis.Frontiers in medicine · 2022Article
- Clinical Features and Influencing Factors for the Prognosis of Patients With Sudden Deafness.Frontiers in neurology · 2022Article
- Editorial: Diagnosis, treatment and prognosis of viral hepatitis, volume II.Frontiers in medicine · 2022Article
- Gastrointestinal Cancers and Liver Cirrhosis: Implications on Treatments and Prognosis.Frontiers in oncology · 2021Review
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11 authors.
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Abstract
BACKGROUND AND
aimsTimely and effective assessment scoring systems for predicting the mortality of patients with hepatitis E virus-related acute liver failure (HEV-ALF) are urgently needed. The present study aimed to establish an effective nomogram for predicting the mortality of HEV-ALF patients.
methodsThe nomogram was based on a cross-sectional set of 404 HEV-ALF patients who were identified and enrolled from a cohort of 650 patients with liver failure. To compare the performance with that of the model for end-stage liver disease (MELD) scoring and CLIF-Consortium-acute-on-chronic liver failure score (CLIF-C-ACLFs) models, we assessed the predictive accuracy of the nomogram using the concordance index (C-index), and its discriminative ability using time-dependent receiver operating characteristics (td-ROC) analysis, respectively.
resultsMultivariate logistic regression analysis of the development set carried out to predict mortality revealed that γ-glutamyl transpeptidase, albumin, total bilirubin, urea nitrogen, creatinine, international normalized ratio, and neutrophil-to-lymphocyte ratio were independent factors, all of which were incorporated into the new nomogram to predict the mortality of HEV-ALF patients. The area under the curve of this nomogram for mortality prediction was 0.671 (95% confidence interval: 0.602-0.740), which was higher than that of the MELD and CLIF-C-ACLFs models. Moreover, the td-ROC and decision curves analysis showed that both discriminative ability and threshold probabilities of the nomogram were superior to those of the MELD and CLIF-C-ACLFs models. A similar trend was observed in the validation set.
conclusionsThe novel nomogram is an accurate and efficient mortality prediction method for HEV-ALF patients.
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