Evidence map›Paper›PMID 34966541›Full record

ArticlePulmonary circulation

Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension.

Ravikumar Sitapara, TuKiet T Lam, Aneta Gandjeva, Rubin M Tuder, Lawrence S Zisman

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ravikumar SitaparaRensselaer Center for Translational Research Inc., Troy, NY, USA.
TuKiet T LamDepartment of Molecular Biophysics and Biochemistry, Yale University, Yale University, New Haven, CT, USA.
Aneta GandjevaProgram in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Rubin M TuderProgram in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Lawrence S ZismanRensselaer Center for Translational Research Inc., Troy, NY, USA.ORCID https://orcid.org/0000-0002-7975-4707
Rensselaer Polytechnic Institute · USUniversity of Colorado Denver · USW. M. Keck Foundation · US

Funding

VRAC and Rho in pulmonary EC proliferationP01HL014985 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1985 to 2019
$35.1M
Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1M
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
Phosphopeptide mapping of plexiform lesions in pulmonary arterial hypertensionR03HL110821 · NHLBI · PULMOKINE, INC. · PI ZISMAN, LAWRENCE S. · 2011 to 2012
$145k
NHLBI NIH HHS P01 HL014985NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R03 HL110821NHLBI NIH HHS R24 HL123767
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a rare disorder associated with high morbidity and mortality despite currently available treatments. We compared the phosphoproteome of lung tissue from subjects with idiopathic PAH (iPAH) obtained at the time of lung transplant with control lung tissue. The mass spectrometry-based analysis found 60,428 phosphopeptide features from which 6622 proteins were identified. Within the subset of identified proteins there were 1234 phosphopeptides with

Indexed as

angiogenesiscell proliferation/cell cycleinflammationproteomicspulmonary hypertension

Identifiers

PMID34966541
PMCPMC8711668
OpenAlexW3180474569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.