ArticleFrontline gastroenterology2022
Widespread gaps in the quality of care for primary biliary cholangitis in UK.
Article in Frontline gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective.Journal of gastroenterology and hepatology · 2026Review
- A Nationwide Assessment of Anticholestatic Therapy Uptake in Patients With Primary Biliary Cholangitis: Opportunities for Optimisation.Alimentary pharmacology & therapeutics · 2026Article
- Epidemiology, comorbidities, treatments and outcomes of autoimmune liver diseases: A French nationwide study.JHEP reports : innovation in hepatology · 2025Article
- Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform.Communications medicine · 2024Article
- Epidemiological trends and outcomes of primary biliary cholangitis in South Korea between 2009 and 2019.Journal of gastroenterology · 2023Article
- UK-PBC National Audit: a collaborative success in identifying critical shortfalls.Frontline gastroenterology · 2023Article
- Article
- Setting Up a Local Registry to Improve the Care of Patients With Primary Biliary Cholangitis.Cureus · 2022Article
- The PBC Ireland patient registry: study protocol for a national platform on primary biliary cholangitis.Therapeutic advances in rare diseaseArticle
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 1 country.
Funding
Abstract
objectivePrimary biliary cholangitis (PBC) is a progressive, autoimmune, cholestatic liver disease affecting approximately 15 000 individuals in the UK. Updated guidelines for the management of PBC were published by The European Association for the Study of the Liver (EASL) in 2017. We report on the first national, pilot audit that assesses the quality of care and adherence to guidelines.
designData were collected from 11 National Health Service hospitals in England, Wales and Scotland between 2017 and 2020. Data on patient demographics, ursodeoxycholic acid (UDCA) dosing and key guideline recommendations were captured from medical records. Results from each hospital were evaluated for target achievement and underwent χ
results790 patients' medical records were reviewed. The data demonstrated that the majority of hospitals did not meet all of the recommended EASL standards. Standards with the lowest likelihood of being met were identified as optimal UDCA dosing, assessment of bone density and assessment of clinical symptoms (pruritus and fatigue). Significant variations in meeting these three standards were observed across UK, in addition to assessment of biochemical response to UDCA (all p<0.0001) and assessment of transplant eligibility in high-risk patients (p=0.0297).
conclusionOur findings identify a broad-based deficiency in 'real-world' PBC care, suggesting the need for an intervention to improve guideline adherence, ultimately improving patient outcomes. We developed the PBC Review tool and recommend its incorporation into clinical practice. As the first audit of its kind, it will be used to inform a future wide-scale reaudit.
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