Evidence map›Paper›PMID 34966462›Full record

ArticleArtery research2021

Statistical Inferences Using Effect Sizes in Human Endothelial Function Research.

Joshua M Cherubini, Maureen J MacDonald

Abstract read
In one paragraph

Article in Artery research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua M CherubiniDepartment of Kinesiology, Vascular Dynamics Lab, McMaster University, Ivor Wynne Centre, Room E210, 1280 Main Street West, Hamilton, ON L8S 4K1 Canada.
Maureen J MacDonaldDepartment of Kinesiology, Vascular Dynamics Lab, McMaster University, Ivor Wynne Centre, Room E210, 1280 Main Street West, Hamilton, ON L8S 4K1 Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMagnitudes of change in endothelial function research can be articulated using effect size statistics. Effect sizes are commonly used in reference to Cohen's seminal guidelines of small (

methodsEffect sizes reported as standardized mean differences were extracted from meta research available for endothelial function. A frequency distribution was constructed to sort effect sizes. The 25th, 50th, and 75th percentiles were used to derive small, medium, and large effects. Group sample sizes and publication year from primary studies were also extracted to observe any potential trends, related to these factors, in effect size reporting in endothelial function research.

resultsSeven hundred fifty-two effect sizes were extracted from eligible meta-analyses. We determined small (

conclusionOur data indicate that direct application of Cohen's guidelines would underestimate the magnitude of effects in human endothelial function research. This investigation facilitates future a priori power analyses, provides a practical guiding benchmark for the contextualization of an effect when no other information is available, and further encourages the reporting of effect sizes in endothelial function research.

Indexed as

Effect sizesEndothelial functionStatistical powerStatistics

Identifiers

PMID34966462
PMCPMC8654719

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.