ArticleFrontiers in microbiology2021
Energy at Origins: Favorable Thermodynamics of Biosynthetic Reactions in the Last Universal Common Ancestor (LUCA).
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent.Science advances · 2026Article
- The Emergence of Life in the Light of Evolution.ArXiv · 2026Article
- QM/MM Modeling of the Electronic Structure and Properties of the Fe-S Clusters inInorganic chemistry · 2026Article
- Non-enzymatic coupling of protometabolic reactions with a prebiotic redox cofactor.Nature communications · 2026Article
- Redox chemistry of early Earth and the origin of life.Communications chemistry · 2026Review
- Reduction of NAD and NMN on mineral surfaces with HCommunications chemistry · 2025Article
- Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections.Open biology · 2025Review
- Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes.Accounts of chemical research · 2024Article
- Chemical Antiquity in Metabolism.Accounts of chemical research · 2024Article
- The radical impact of oxygen on prokaryotic evolution-enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third.FEBS letters · 2024Article
- Article
- Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Biophysical Interactions Underpin the Emergence of Information in the Genetic Code.Life (Basel, Switzerland) · 2023Article
- Design of a minimal di-nickel hydrogenase peptide.Science advances · 2023Article
- Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life.Frontiers in microbiology · 2023Review
- Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria.Nature communications · 2022Article
- Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- The limits of metabolic heredity in protocells.Proceedings. Biological sciences · 2022Article
- A Short Tale of the Origin of Proteins and Ribosome Evolution.Microorganisms · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Though all theories for the origin of life require a source of energy to promote primordial chemical reactions, the nature of energy that drove the emergence of metabolism at origins is still debated. We reasoned that evidence for the nature of energy at origins should be preserved in the biochemical reactions of life itself, whereby changes in free energy, Δ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.