Evidence map›Paper›PMID 34966357›Full record

ArticleFrontiers in endocrinology2021

Six Air Pollutants Associated With Increased Risk of Thyroid Nodules: A Study of 4.9 Million Chinese Adults.

Yunjing Zhang, Kai Wang, Wei Qin, Cheng Jin, Yiqing Song, Peng Jia, Shengfeng Wang, Yongfeng Song, Yi Ning, Liming Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Association Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review.Thyroid : official journal of the American Thyroid Association · 2024
    Pooled it
  2. Review
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  4. Article
  5. Article
  6. Article
  7. Association between long-term exposure to PMEnvironmental health : a global access science source · 2025
    Article
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  13. Review
  14. Article
  15. Effect of the Marine Exercise Retreat Program on Thyroid-Related Hormones in Middle-Aged Euthyroid Women.International journal of environmental research and public health · 2023
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yunjing ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China.
Kai WangDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Wei QinDepartment of Social Medicine and Health Education, School of Public Health, PKUHSC, Beijing, China.
Cheng JinMeinian Institute of Health, Beijing, China.
Yiqing SongDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, United States.
Peng JiaSchool of Resources and Environmental Science, Wuhan University, Wuhan, China.
Shengfeng WangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China.
Yongfeng SongDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yi NingMeinian Institute of Health, Beijing, China.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China.
Peking University · CNShandong Provincial Hospital · CNChina National Health Development Research Center · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thyroid nodules has become a significant public health issue worldwide with a rapidly increasing prevalence. However, its association with outdoor air pollution remains poorly understood. We aim to investigate the relationship between six outdoor air pollutants (PM Methods: We utilized a database including 4,920,536 participants who attended the annual physical examinations in the Meinian HealthCare Screening Center in 157 Chinese cities in 2017. City-specific concentrations of six pollutants (PM Results: Approximately 38% of the participants (1,869,742) were diagnosed with thyroid nodules. Each of the six air pollutants was significantly and linearly associated with the risk for thyroid nodules. The adjusted odds ratios [95% CI] for every increase of 10 μg/m Conclusion: The six air pollutants may contribute to the high prevalence of thyroid nodules in China.

Indexed as

AdolescentAdultAgedAged, 80 and overAir PollutantsAir PollutionCarbon MonoxideChinaEnvironmental MonitoringFemaleHumansIodineLipidsMaleMiddle AgedNitric OxideAir PollutantsCarbon MonoxideIodineLipidsNitric OxideOzoneParticulate MatterSulfur DioxideCOdose–response relationshipNO2O3PM10PM2.5SO2thyroid nodules

Identifiers

PMID34966357
PMCPMC8710776
OpenAlexW4200178271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.