ArticleFrontiers in neuroscience2021
40 Hz Light Flicker Alters Human Brain Electroencephalography Microstates and Complexity Implicated in Brain Diseases.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Neurobiological mechanisms of 40-Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Dual-pathway inhibitory dysfunction in schizophrenia: MEG and behavioral markers for risk stratification.Journal of psychiatry & neuroscience : JPN · 2026Article
- From the Ocular Surface to Neurophysiology: An Integrative Review of Digital Eye Strain.Clinical optometry · 2026Review
- Microstate Dynamics Alterations in Response To 40 Hz Rhythmic Light Intervention in Mild Cognitive Impairment.Brain topography · 2025Article
- Chronic 40 Hz light flicker mitigates epileptogenesis through a visual pathway associated with the dorsal lateral geniculate nucleus shell.Nature communications · 2025Article
- Parvalbumin Interneuron-Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Preliminary study of sex-based neural responses and cognitive benefits of a 40 Hz rhythmic light intervention in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- 40 Hz light stimulation restores early brain dynamics alterations and associative memory in Alzheimer's disease model mice.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment.Journal of central nervous system disease · 2025Review
- Mystery of gamma wave stimulation in brain disorders.Molecular neurodegeneration · 2024Review
- A finer-grained high altitude EEG dataset for hypoxia levels assessment.Scientific data · 2024Article
- A Lightweight Multi-Mental Disorders Detection Method Using Entropy-Based Matrix from Single-Channel EEG Signals.Brain sciences · 2024Article
- Beyond Frequency Bands: Complementary-Ensemble-Empirical-Mode-Decomposition-Enhanced Microstate Sequence Non-Randomness Analysis for Aiding Diagnosis and Cognitive Prediction of Dementia.Brain sciences · 2024Article
- 40 Hz light flickering promotes sleep through cortical adenosine signaling.Cell research · 2024Article
- Audiovisual gamma stimulation for the treatment of neurodegeneration.Journal of internal medicine · 2024Review
- Resting-state EEG microstates as electrophysiological biomarkers in post-stroke disorder of consciousness.Frontiers in neuroscience · 2023Article
- Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer's Disease continuum?NeuroImage. Clinical · 2023Article
- Gamma oscillations and application of 40-Hz audiovisual stimulation to improve brain function.Brain and behavior · 2022Review
- Time Is of the Essence: Neural Codes, Synchronies, Oscillations, Architectures.Frontiers in computational neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies showed that entrainment of light flicker at low gamma frequencies provided neuroprotection in mouse models of Alzheimer's disease (AD) and stroke. The current study was set to explore the feasibility of using 40 Hz light flicker for human brain stimulation for future development as a tool for brain disease treatment. The effect of 40 Hz low gamma frequency light on a cohort of healthy human brains was examined using 64 channel electroencephalography (EEG), followed by microstate analyses. A random frequency light flicker was used as a negative control treatment. Light flicker at 40 Hz significantly increased the corresponding band power in the O1, Oz, and O3 electrodes covering the occipital areas of both sides of the brain, indicating potent entrainment with 40 Hz light flicker in the visual cortex area. Importantly, the 40 Hz light flicker significantly altered microstate coverage, transition duration, and the Lempel-Ziv complexity (LZC) compared to the rest state. Microstate metrics are known to change in the brains of Alzheimer's disease, schizophrenia, and stroke patients. The current study laid the foundation for the future development of 40 Hz light flicker as therapeutics for brain diseases.
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