ArticleJournal of the ASEAN Federation of Endocrine Societies2021
Discordance between Fasting Plasma Glucose (FPG) and HbA1c in Diagnosing Diabetes and Pre-diabetes in The Malaysian Cohort.
Article in Journal of the ASEAN Federation of Endocrine Societies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- miRNAs as potential biomarkers for early detection of prediabetes among obesity: a systematic review.Bioscience reports · 2025Pooled it
- Effects of a Text Message-Based Lifestyle Intervention on HbA1c and Health Behaviors in Older Adults with Prediabetes.Nutrients · 2026Trial
- Article
- Validity of hemoglobin A1C for screening prediabetes and diabetes in the Iranian population: analysis of National surveillance data.Scientific reports · 2026Article
- Identification of differentially expressed plasma small extracellular vesicles miRNAs as biomarkers for type 2 diabetes.Frontiers in endocrinology · 2026Article
- Undiagnosed Diabetes and Prediabetes in Yemen: A Growing Public Health Crisis in the Shadow of Conflict.Medicina (Kaunas, Lithuania) · 2025Article
- Short and Long term glycemic control among Type 2 DM patients in a resource-limited setting.African health sciences · 2025Article
- Measuring Hemoglobin A1C with Frozen Packed Cell and Frozen Whole Blood Samples in an Epidemiologic Study: The Reasons for Geographic and Racial Differences in Stroke Study.Journal of clinical laboratory analysis · 2025Article
- Continuous Glucose Monitoring for Prediabetes: What Are the Best Metrics?Journal of diabetes science and technology · 2024Review
- Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c.Nature medicine · 2023Article
- Stability of glycated haemoglobin (HbA1c) measurements from whole blood samples kept at -196°C for seven to eight years in The Malaysian Cohort study.Journal of clinical laboratory analysis · 2023Article
- Causal Relationships Between Glycemic Traits and Myopia.Investigative ophthalmology & visual science · 2023Article
- Prevalence of haemoglobin A1c based dysglycaemia among adult community dwellers in selected states in Nigeria: a descriptive cross-sectional study.Frontiers in endocrinology · 2023Article
- Causal relationships between type 2 diabetes, glycemic traits and keratoconus.Frontiers in medicine · 2023Article
- The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study.Frontiers in public health · 2023Article
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Authors and funding
8 authors.
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Abstract
objectiveIn this present study, we aim to evaluate the accuracy of the HbA1c relative to fasting plasma glucose (FPG) in the diagnosis of diabetes and pre-diabetes among The Malaysian Cohort (TMC) participants. METHODOLOGY: FPG and HbA1c were taken from 40,667 eligible TMC participants that have no previous history of diabetes, aged between 35-70 years and were recruited from 2006 - 2012. Participants were classified as normal, diabetes and pre-diabetes based on the 2006 World Health Organization (WHO) criteria. Statistical analyses were performed using ANOVA and Chi-square test, while Pearson correlation and Cohen's kappa were used to examine the concordance rate between FPG and HbA1c.
resultsThe study samples consisted of 16,224 men and 24,443 women. The prevalence of diabetes among the participants was 5.7% and 7.5% according to the FPG and HbA1c level, respectively. Based on FPG, 10.6% of the participants had pre-diabetes but this increased to 14.2% based on HbA1c (r=0.86;
conclusionA higher prevalence of pre-diabetes and diabetes was observed when using HbA1c as a diagnosis tool, suggesting that it could possibly be more useful for early detection. However, given that HbA1c may also have lower sensitivity and higher false positive rate, several diagnostic criteria should be used to diagnose diabetes accurately.
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