Evidence map›Paper›PMID 34965974›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation.

Daniel D Lam, Rhîannan H Williams, Ernesto Lujan, Koji Tanabe, Georg Huber, Nay Lui Saw, Juliane Merl-Pham, Aaro V Salminen, David Lohse, Sally Spendiff and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Daniel D LamInstitute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany juliane.winkelmann@tum.de danlam3@gmail.com.
Rhîannan H WilliamsInstitute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.
Ernesto LujanInstitute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University, Stanford, California 94305.
Koji TanabeInstitute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University, Stanford, California 94305.
Georg HuberProtein Expression and Purification Facility, Institute of Structural Biology, Helmholtz Zentrum München, Munich, Germany.
Nay Lui SawDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, California 94304.
Juliane Merl-PhamResearch Unit Protein Science, Helmholtz Zentrum München, Munich, Germany.
Aaro V SalminenInstitute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.
David LohseInstitute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.
Sally SpendiffChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 5B2, Canada.
Melanie J PlastiniDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California 94304.
Michael ZechInstitute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.
Hanns LochmüllerChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 5B2, Canada.
Arie GeerlofProtein Expression and Purification Facility, Institute of Structural Biology, Helmholtz Zentrum München, Munich, Germany.
Stefanie M HauckResearch Unit Protein Science, Helmholtz Zentrum München, Munich, Germany.ORCID 0000-0002-1630-6827
Mehrdad ShamlooDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, California 94304.
Marius WernigInstitute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University, Stanford, California 94305.
Juliane WinkelmannInstitute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany juliane.winkelmann@tum.de danlam3@gmail.com.
Helmholtz Zentrum München · DECalifornia Institute for Regenerative Medicine · USPalo Alto University · USChildren's Hospital of Eastern Ontario · CAStanford University · USUniversity of Ottawa · CA

Funding

CIHR FDN-167281
6 · The paper itself

Abstract

Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing the movement disorder dystonia. To elucidate the neurophysiological role of collagen VI, we generated mice with a truncation of the dystonia-related collagen α3 VI (COL6A3) C-terminal domain (CTD). These

Indexed as

CannabinoidsCollagen Type VIDystoniaDystonic DisordersMotor NeuronsNeuronal PlasticityAnimalsFemaleMaleMiceMutationReceptors, CannabinoidCannabinoidsCollagen Type VIReceptors, Cannabinoidbasal pontine nucleicannabinoid receptorcollagen VIdystoniaendocannabinoidsynaptic homeostasis

Identifiers

PMID34965974
PMCPMC8883874
OpenAlexW4220710346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.