Evidence map›Paper›PMID 34965972›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Distinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older Adults.

Jenna N Adams, Theresa M Harrison, Anne Maass, Suzanne L Baker, William J Jagust

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Spatial patterns of tau accumulation across the Alzheimer's disease spectrum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Tau accumulation and atrophy predict amyloid independent cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Entorhinal-Hippocampal Circuit Integrity Is Related to Mnemonic Discrimination and Amyloid-β Pathology in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jenna N AdamsHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 jnadams@berkeley.edu.ORCID 0000-0002-6702-3851
Theresa M HarrisonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.
Anne MaassHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, California 94720.ORCID 0000-0003-0209-3127
William J JagustHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.ORCID 0000-0002-4458-113X
Lawrence Berkeley National Laboratory · USUniversity of California, Berkeley · USGerman Center for Neurodegenerative Diseases · DE

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Tracking Tau with In Vivo Braak Staging: Longitudinal Analysis of Tau Pathology and Functional Sequelae in Cognitively Healthy Older AdultsF32AG057107 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRISON, THERESA M. · 2017 to 2020
$124k
Tracking tau spread through functional connectivity networks in agingF31AG062090 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, JENNA NICOLE · 2019 to 2020
$63k
NIA NIH HHS F31 AG062090NIA NIH HHS F32 AG057107NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG062542
6 · The paper itself

Abstract

Mechanisms underlying the initial accumulation of tau pathology across the human brain are largely unknown. We examined whether baseline factors including age, amyloid-β (Aβ), and neural activity predicted longitudinal tau accumulation in temporal lobe regions that reflect distinct stages of tau pathogenesis. Seventy cognitively normal human older adults (77 ± 6 years, 59% female) received two or more

Indexed as

AgedAged, 80 and overAgingAmyloid beta-PeptidesBrainFemaleHumansMalePositron-Emission TomographyRisk Factorstau ProteinsAmyloid beta-PeptidesMAPT protein, humantau ProteinsagingAlzheimer's diseaseamyloid-βfMRIPETtau

Identifiers

PMID34965972
PMCPMC8883857
OpenAlexW4200187819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.