Evidence map›Paper›PMID 34965897›Full record

ReviewHearing research2022

Of mice and chickens: Revisiting the RC time constant problem.

Kuni H Iwasa

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hearing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kuni H IwasaNIDCD, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kuni.iwasa@gmail.com.
National Institutes of Health · US

Funding

BIOPHYSICAL STUDY OF SENSORY TRANSDUCTION MECHANISMSZ01DC000010 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI IWASA, KUNI H · 1992 to 2008
$1.6M
Intramural NIH HHS Z01 DC000010
6 · The paper itself

Abstract

Avian hair cells depend on electrical resonance for frequency selectivity. The upper bound of the frequency range is limited by the RC time constant of hair cells because the sharpness of tuning requires that the resonance frequency must be lower than the RC roll-off frequency. In contrast, tuned mechanical vibration of the inner ear is the basis of frequency selectivity of the mammalian ear. This mechanical vibration is supported by outer hair cells (OHC) with their electromotility (or piezoelectricity), which is driven by the receptor potential. Thus, it is also subjected to the RC time constant problem. Association of OHCs with a system with mechanical resonance leads to piezoelectric resonance. This resonance can nullify the membrane capacitance and solves the RC time constant problem for OHCs. Therefore, avian and mammalian ears solve the same problem in the opposite way. This article is part of the Special Issue Outer hair cell Edited by Joseph Santos-Sacchi and Kumar Navaratnam.

Indexed as

ChickensHair Cells, Auditory, OuterAnimalsElectric CapacitanceMammalsAuditory frequenciesElectrical resonanceMembrane capacitancePiezoelectric resonance

Identifiers

PMID34965897
PMCPMC12220766
OpenAlexW3176029642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.