Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 5 institutions in 1 country.
David Izquierdo-GarciaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0003-0763-8827
Himashinie DiyabalanageCollagen Medical, LLC, Belmont, MA (H.D., I.A.R., V.H.).
Ian A RamsayAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0003-1896-4337
Nicholas J RotileAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.
Adam MauskapfCardiovascular Research Center, Division of Cardiology, Department of Medicine (A.M., F.A.J.), Massachusetts General Hospital and Harvard Medical School, Boston.
Ji-Kyung ChoiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0003-1842-8825
Thomas WitzelAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.
Farouc A JafferCardiovascular Research Center, Division of Cardiology, Department of Medicine (A.M., F.A.J.), Massachusetts General Hospital and Harvard Medical School, Boston.ORCID 0000-0001-7980-384X
Anna-Liisa BrownellGordon Center for Medical Imaging, Department of Radiology (A.-L.B.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0002-3814-868X
Ahmed TawakolNuclear Cardiology, Division of Cardiology, Department of Medicine (A.T.), Massachusetts General Hospital and Harvard Medical School, Boston.ORCID 0000-0002-9211-5483
Ciprian CatanaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0002-3249-5971
Mark F ConradDivision of Vascular and Endovascular Surgery (M.F.C.), Massachusetts General Hospital and Harvard Medical School, Boston.ORCID 0000-0001-6625-8889
Peter Caravan *Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0002-3179-6537
Ilknur Ay *Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.I.-G., I.A.R., N.J.R., J.-K.C., T.W., C.C., P.C., I.A.), Massachusetts General Hospital and Harvard Medical School, Charlestown.ORCID 0000-0001-9558-742X
Athinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · USCollagen Medical (United States) · USGordon Center for Medical Imaging · USHarvard–MIT Division of Health Sciences and Technology · US
Funding
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 1999 to 2011
$16.4M
PET Imaging of ThrombusR01HL109448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, SOSNOVIK, DAVID E · 2011 to 2025
$9.6M
Intravascular NIRF-IVUS imaging of inflammation-guided arterial therapyR01HL150538 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2020 to 2023
$2.2M
NIRF-OFDI of Inflammation in Atheroma Progression and Stent ComplicationsR01HL122388 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2015 to 2018
$2.1M
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
Molecular Imaging Agent to Detect ThrombusR44HL156606 · NHLBI · COLLAGEN MEDICAL, LLC · PI HUMBLET, VALERIE · 2021 to 2021
$497k
HPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371k
Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
background and purposeHigh-risk atherosclerosis is an underlying cause of cardiovascular events, yet identifying the specific patient population at immediate risk is still challenging. Here, we used a rabbit model of atherosclerotic plaque rupture and human carotid endarterectomy specimens to describe the potential of molecular fibrin imaging as a tool to identify thrombotic plaques.
methodsAtherosclerotic plaques in rabbits were induced using a high-cholesterol diet and aortic balloon injury (N=13). Pharmacological triggering was used in a group of rabbits (n=9) to induce plaque disruption. Animals were grouped into thrombotic and nonthrombotic plaque groups based on gross pathology (gold standard). All animals were injected with a novel fibrin-specific probe
resultsBoth tissue-to-background (back muscle) ratios and standardized uptake value were significantly higher in the thrombotic versus nonthrombotic group (
conclusionsWe demonstrated that molecular fibrin PET imaging using
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe. · full record | OpenQuestion