ArticleJournal of proteome research2022
The Influence of Storage on Human Milk Lipidome Stability for Lipidomic Studies.
Article in Journal of proteome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Impact of Pasteurization and Storage on the Microbiological Composition and Lipid Degradation of Human Milk Cream.Foods (Basel, Switzerland) · 2026Article
- Concentration and Intakes of Macronutrients from Human Milk Do Not Differ by Infant Sex in Australian and Danish Cohorts.Nutrients · 2025Article
- Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research.Advances in nutrition (Bethesda, Md.) · 2022Article
- Quantification of phospholipids and glycerides in human milk using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry.Frontiers in chemistry · 2022Article
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Authors and funding
4 authors.
Funding
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Abstract
Human milk (HM) lipidome stability during storage is crucial in lipidomic studies to avoid misinterpretations. Facing the lack of comprehensive work on the HM lipidome stability, we performed a study on a potential alteration in the lipid profiles of HM samples stored under different conditions. An untargeted LC-Q-TOF-MS-based approach was applied to study the influence of storage conditions as well as the interaction of the storage temperature and time on HM lipid profiles. The samples were stored for 4-84 days at temperatures in the range from 4 to -80 °C and also were exposed to up to three freeze-thaw cycles. The results showed that the storage at 4 °C for just 4 days as well as being subjected to three freeze-thaw cycles can lead to a change in the content of lipids. The observed differences in levels of some lipid species in samples stored at -20 °C in comparison to the concentration level of those lipids in samples stored at -80 °C were not statistically significant, and inter-individual variance regardless of sample storage condition was maintained. The storage of HM samples at -20 °C for up to 3 weeks and -80 °C for up to 12 weeks ensures sample lipidome stability.
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