Evidence map›Paper›PMID 34965617›Full record

ArticleJournal of periodontal & implant science2021

Adjuvant therapy with 1% alendronate gel for experimental periodontitis treatment in rats.

Natália de Campos Kajimoto, Yvonne de Paiva Buischi, Peter Michael Loomer, Timothy G Bromage, Edilson Ervolino, Stephen Enrico Fucini, Natália Marcumini Pola, Beatriz Ommati Pirovani, Maria Juliana Sismeiro Morábito, Juliano Milanezi de Almeida and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal & implant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Natália de Campos KajimotoDepartment of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. periodontia.natalia@gmail.com.ORCID https://orcid.org/0000-0001-7245-5213
Yvonne de Paiva BuischiDepartment of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID https://orcid.org/0000-0001-6716-8957
Peter Michael LoomerDepartment of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID https://orcid.org/0000-0002-4676-0895
Timothy G BromageDepartment of Biomaterials & Biomimetics, New York University College of Dentistry, New York, NY, USA.ORCID https://orcid.org/0000-0002-9843-7993
Edilson ErvolinoDivision of Histology, Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.ORCID https://orcid.org/0000-0003-4859-0583
Stephen Enrico FuciniPrivate Practice, Hanover, NH, USA.ORCID https://orcid.org/0000-0002-7711-7907
Natália Marcumini PolaDivision of Periodontics, Department of Semiology and Clinic, Federal University of Pelotas (UFPEL), School of Dentistry, Pelotas, RS, Brazil.ORCID https://orcid.org/0000-0001-9188-7337
Beatriz Ommati PirovaniDivision of Periodontology, Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.ORCID https://orcid.org/0000-0003-4536-6674
Maria Juliana Sismeiro MorábitoDivision of Periodontology, Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.ORCID https://orcid.org/0000-0002-8913-0914
Juliano Milanezi de AlmeidaDivision of Periodontology, Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.ORCID https://orcid.org/0000-0002-5995-5747
Flávia Aparecida Chaves FurlanetoDivision of Periodontology, Departament of Oral Maxillofacial Surgery and Periodontology, University of São Paulo (USP), School of Dentistry, Ribeirão Preto, SP, Brazil.ORCID https://orcid.org/0000-0002-8072-3983
Maria José Hitomi NagataDivision of Periodontology, Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.ORCID https://orcid.org/0000-0001-5903-5652
Universidade Estadual Paulista (Unesp) · BRThe University of Texas Health Science Center at San Antonio · USHanover College · USNew York University · USUniversidade de São Paulo · BRUniversidade Federal de Pelotas · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo #18/03331-1
6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy.

methodsLigature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at

resultsThe SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (

conclusionsLocally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.

Indexed as

AlendronateDental scalingPeriodontal diseasePeriodontitisRats

Identifiers

PMID34965617
PMCPMC8718338
OpenAlexW3166442069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.