Evidence map›Paper›PMID 34965548›Full record

ArticleProblemy radiatsiinoi medytsyny ta radiobiolohii2021

THYROID SCREENING AND RELIABILITY OF RADIATION THYROID DOSES FOR THE BELARUSIAN IN UTERO COHORT.

V Drozdovitch, V V Yauseyenka, V F Minenko, I V Veyalkin, T S Kukhta, R I Grakovitch, S Trofimik, O N Polyanskaya, L Starastsenka, E K Cahoon and 6 more

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In one paragraph

Article in Problemy radiatsiinoi medytsyny ta radiobiolohii, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

V DrozdovitchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
V V YauseyenkaRepublican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel, 246040, Belarus.
V F MinenkoInstitute for Nuclear Problems, Belarusian State University, 11 Bobruiskaya Street, Minsk, 220006, Belarus.
I V VeyalkinRepublican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel, 246040, Belarus.
T S KukhtaJoint Institute of Informatics Problems, National Academy of Sciences of Belarus, 6 Surhanava Street, Minsk, 220012, Belarus.
R I GrakovitchRepublican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel, 246040, Belarus.
S TrofimikInstitute for Nuclear Problems, Belarusian State University, 11 Bobruiskaya Street, Minsk, 220006, Belarus.
O N PolyanskayaRepublican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel, 246040, Belarus.
L StarastsenkaRepublican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel, 246040, Belarus.
E K CahoonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
M HatchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
M P LittleDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
A V BrennerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
E OstroumovaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
K MabuchiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892-9778, USA.
A V RozhkoRepublican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel, 246040, Belarus.
Republican Research Center for Radiation Medicine and Human Ecology · BYNational Cancer Institute · USNational Institutes of Health · USBelarusian State University · BYNational Academy of Sciences of Belarus · BYRadiation Effects Research Foundation · JP

Funding

Intramural NIH HHS Z99 CA999999NCI NIH HHS HHSN261201300002CNCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015IWorld Health Organization 001
6 · The paper itself

Abstract

objectiveTo describe the status and results of thyroid disease screening and assessment of reliability of radiationthyroid doses in the Belarusian in utero cohort of 2,965 individuals exposed to Chernobyl (Chornobyl) fallout. MATERIALS AND

methodsThyroid screening examinations are currently underway including thyroid palpation by anendocrinologist, ultrasonographic examination by an ultrasonographer and analysis of blood samples for diagnosisof hypo- and hyperthyroidism, autoimmune thyroiditis, thyroid function tests (thyroid-stimulating hormone [TSH],thyroxine [T4], thyroid peroxidase antibody [anti-TPO], and thyroglobulin antibodies [anti-TG]). Reliability of (i)information from 780 pairs of questionnaires obtained during the first and second interviews of the mothers and (ii)thyroid doses, which were calculated for the cohort members using this information, is evaluated.

resultsAs of 15 August 2021, 1,267 in utero exposed study subjects had been screened. A single thyroid nodule wasdiagnosed in 167 persons (13.2 % of the total) and multiple thyroid nodules in 101 persons (8.0 %): 189 (14.9 %)persons had nodules detected for the first time at the screening while 79 (6.2 %) persons had nodules detected pre-viously (pre-screening nodules). Fifty-nine out of 268 subjects (22.0 %) with a suspicious thyroid nodule werereferred to fine needle aspiration biopsy, and among them 33 (55.9 %) were biopsied. Reasonable agreement wasobserved for modelqbased doses calculated for the Belarusian in utero cohort members using data from the two inter-views (Spearman's rank-correlation coefficient rs = 0.74, p < 0.001), while measurementqbased doses yielded almost per-fect agreement (rs = 0.99, p < 0.001).

conclusionsDuring the thyroid screening, at least one thyroid nodule was identified in 268 of 1,267 (21.2 %) inutero exposed cohort members. Seven thyroid cancer cases were identified in the cohort, including 5 pre-screeningcases and 2 cases detected during the screening. Ongoing research on this unique cohort will provide importantinformation on adverse health effects following prenatal and postnatal exposure to radioiodine and radiocesium iso-topes, for which available epidemiological data are scant.

Indexed as

Chernobyl Nuclear AccidentPregnant PeopleRadiation DosageAdultCohort StudiesFemaleFetusHumansInfant, NewbornLongitudinal StudiesMaleMaternal ExposureNeoplasms, Radiation-InducedPregnancyPrenatal Exposure Delayed EffectsRadioactive FalloutRadioactive FalloutChernobylChornobylearly lifeexposurein uteroreliabilitythyroid cancer

Identifiers

PMID34965548
PMCPMC9476699
OpenAlexW4200228476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.