Evidence map›Paper›PMID 34965439›Full record

ArticleCell reports2021

Secreted osteopontin from CD4

Nupur Aggarwal, M Elizabeth Deerhake, Devon DiPalma, Shailesh K Shahi, Margaret R Gaggioli, Ashutosh K Mangalam, Mari L Shinohara

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Gut microbiota and neonatal acute kidney injury biomarkers.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Definition of the contribution of an Osteopontin-producing CD11cProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nupur AggarwalDepartment of Immunology, Duke University Medical School, Durham, NC 27710, USA.
M Elizabeth DeerhakeDepartment of Immunology, Duke University Medical School, Durham, NC 27710, USA.
Devon DiPalmaDepartment of Immunology, Duke University Medical School, Durham, NC 27710, USA.
Shailesh K ShahiDepartment of Pathology, University of Iowa, Iowa City, IA 52242, USA.
Margaret R GaggioliDepartment of Molecular Genetics and Microbiology, Duke University Medical School, Durham, NC 27710, USA.
Ashutosh K MangalamDepartment of Pathology, University of Iowa, Iowa City, IA 52242, USA.
Mari L ShinoharaDepartment of Immunology, Duke University Medical School, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical School, Durham, NC 27710, USA. Electronic address: mari.shinohara@duke.edu.
Duke University · USUniversity of Iowa · US

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Role of osteopontin in innate immunity during infections and inflammationR01AI088100 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2011 to 2021
$4.3M
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infectionsR01AI160737 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.7M
Protective role of dectin-1 signaling in an animal model of Multiple SclerosisF30AI140497 · NIAID · DUKE UNIVERSITY · PI DEERHAKE, MARION ELIZABETH · 2018 to 2021
$169k
STRUCTURAL ANALYSIS OF THE DELTA ANTIGEN OF HDVF32AI008810 · NIAID · ROCKEFELLER UNIVERSITY · PI NAJITA, LYE M · 1993 to 1995
–
NIAID NIH HHS F30 AI140497NIAID NIH HHS F32 AI008810NIAID NIH HHS R01 AI088100NIAID NIH HHS R01 AI160737NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Osteopontin (OPN) has been considered a potential biomarker of graft-versus-host disease (GVHD). However, the function of OPN in GVHD is still elusive. Using a mouse model of acute GVHD (aGVHD), we report that OPN generated by CD4

Indexed as

AnimalsEpithelial CellsFemaleGraft vs Host DiseaseHyaluronan ReceptorsIntestinesMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutOsteopontinT-LymphocytesCd44 protein, mouseHyaluronan ReceptorsOsteopontinSpp1 protein, mouseCD44cell deathgraft-versus-host disease (GVHD)intestinal epithelial cells (IECs)intracellular osteopontin (iOPN)microbiomesecreted osteopontin (sOPN)

Identifiers

PMID34965439
PMCPMC8759344
OpenAlexW4200182983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.