Evidence map›Paper›PMID 34965181›Full record

ArticleGut microbes

Autophagy mediates ER stress and inflammation in

M C Mommersteeg, I Simovic, B Yu, S A V van Nieuwenburg, I M J Bruno, M Doukas, E J Kuipers, M C W Spaander, M P Peppelenbosch, N Castaño-Rodríguez and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Subtype-specific associations of steatotic liver disease with gastric and esophageal cancers: a nationwide cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. EnterohemorrhagicPathogens (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Review
  20. Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

M C MommersteegDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
I SimovicSchool of Biotechnology and Biomolecular Sciences, Unsw, Sydney, Australia.
B YuDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
S A V van NieuwenburgDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
I M J BrunoDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-9181-5499
M DoukasDepartment of Pathology, Erasmus University Medical Center, Rotterdam, Netherlands.ORCID 0000-0002-8611-840X
E J KuipersDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-0633-3098
M C W SpaanderDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
M P PeppelenboschDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
N Castaño-RodríguezSchool of Biotechnology and Biomolecular Sciences, Unsw, Sydney, Australia.
G M FuhlerDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Erasmus MC · NLUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a cellular degradation mechanism, which is triggered by the bacterium

Indexed as

AutophagyEndoplasmic Reticulum StressAdultAgedAustraliaAutophagy-Related ProteinsCohort StudiesDisease ProgressionFemaleGastrointestinal MicrobiomeHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedNetherlandsATG16L1 protein, humanAutophagy-Related ProteinsATG16L1atrophic gastritisautophagyER stressgastric cancerHelicobacter pyloriinflammationIntestinal metaplasia

Identifiers

PMID34965181
PMCPMC8726742
OpenAlexW4206731648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.