Evidence map›Paper›PMID 34965180›Full record

ArticleGut microbes

Loss-of-function

Shannon L Kelleher, Samina Alam, Olivia C Rivera, Shiran Barber-Zucker, Raz Zarivach, Takumi Wagatsuma, Taiho Kambe, David I Soybel, Justin Wright, Regina Lamendella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Modulation of intestinal TLR4 expression in infants with neonatal opioid withdrawal syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Shannon L KelleherDepartment of Cellular and Molecular Physiology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-0613-6294
Samina AlamDepartment of Cellular and Molecular Physiology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA.
Olivia C RiveraDepartment of Cellular and Molecular Physiology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA.
Shiran Barber-ZuckerDepartment of Life Sciences, The National Institute for Biotechnology in the Negev and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Raz ZarivachDepartment of Life Sciences, The National Institute for Biotechnology in the Negev and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Takumi WagatsumaThe Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Taiho KambeThe Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
David I SoybelDepartment of Surgery, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA.
Justin WrightDepartment of Biology, Juniata College, Huntingdon, Pennsylvania, USA.
Regina LamendellaDepartment of Biology, Juniata College, Huntingdon, Pennsylvania, USA.
Penn State Milton S. Hershey Medical Center · USBen-Gurion University of the Negev · ILJuniata College · USKyoto University · JPUniversity of Massachusetts Lowell · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of Paneth cell (PC) function is implicated in intestinal dysbiosis, mucosal inflammation, and numerous intestinal disorders, including necrotizing enterocolitis (NEC). Studies in mouse models show that zinc transporter ZnT2 (

Indexed as

Loss of Function MutationAnimalsBacteriaCation Transport ProteinsDysbiosisExonsFemaleGastrointestinal MicrobiomeHumansInfant, NewbornInfant, Newborn, DiseasesInfant, PrematureIntestinesMaleMiceMice, KnockoutCation Transport ProteinsPolysaccharidesSLC30A2 protein, humanhost–microbe interactionsinfancymicrobiomeSLC30A2ZincZnT2

Identifiers

PMID34965180
PMCPMC8726655
OpenAlexW4206532347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.