Evidence map›Paper›PMID 34964874›Full record

ArticleJournal of athletic training2022

Age- and Sex-Specific Joint Biomechanics in Response to Partial and Complete Anterior Cruciate Ligament Injury in the Porcine Model.

Danielle Howe, Stephanie G Cone, Jorge A Piedrahita, Jeffrey T Spang, Matthew B Fisher

Open access · diamondAbstract read
In one paragraph

Article in Journal of athletic training, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Danielle HoweJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh.
Stephanie G ConeJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh.
Jorge A PiedrahitaComparative Medicine Institute, North Carolina State University, Raleigh.
Jeffrey T SpangDepartment of Orthopaedics, School of Medicine, University of North Carolina, Chapel Hill.
Matthew B FisherJoint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh.
North Carolina State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Sex- and Age-dependent ACL Function in the Growing Knee JointR01AR071985 · NIAMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Matthew B Fisher · 2018 to 2026
$3.6M
Age-Dependent ACL Function During Growth: Guiding Injury Treatment in ChildrenR03AR068112 · NIAMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI FISHER, MATTHEW B · 2015 to 2017
$227k
Effect of Age, Sex, and Injury on Regional Stresses and Resulting Growth of the Anterior Cruciate LigamentF31AR077997 · NIAMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOWE, DANIELLE · 2021 to 2022
$54k
NIAMS NIH HHS F31 AR077997NIAMS NIH HHS R01 AR071985NIAMS NIH HHS R03 AR068112
6 · The paper itself

Abstract

contextPediatric anterior cruciate ligament (ACL) injury rates are increasing and are highest in female adolescents. Complete ACL tears are typically surgically reconstructed, but few guidelines and very limited data exist regarding the need for surgical reconstruction or rehabilitation for partial ACL tears in skeletally immature patients.

objectiveTo evaluate the effects of partial (anteromedial bundle) and complete ACL transection on joint laxity and tissue forces under anterior and rotational loads in male and female stifle joints throughout skeletal growth in the porcine model.

designDescriptive laboratory study.

settingLaboratory. PATIENTS OR OTHER

participantsWe studied 60 male and female Yorkshire crossbreed pigs aged 1.5, 3, 4.5, 6, and 18 months (n = 6 pigs per age per sex). MAIN OUTCOME MEASURE(S): Joint laxity was measured in intact, anteromedial bundle-transected, and ACL-transected joints under applied anterior-posterior drawer and varus-valgus torque using a robotic testing system. Loading of the soft tissues in the stifle joint was measured under each condition.

resultsAnterior-posterior joint laxity increased by 13% to 50% (P < .05) after anteromedial bundle transection and 75% to 178% (P < .05) after ACL transection. Destabilization after anteromedial bundle transection increased with age (P < .05) and was greater in late female than late male adolescents (P < .05). In anteromedial bundle-transected joints, the posterolateral bundle resisted the anterior load. In ACL-transected joints, the medial collateral ligament (MCL) contribution was largest, followed by the medial meniscus. The MCL contribution was larger and the medial meniscus contribution was smaller in male versus female specimens.

conclusionsPartial ACL transection resulted in moderate increases in joint laxity, with the remaining bundle performing the primary ACL function. Destabilization due to partial ACL transection (anteromedial bundle) was largest in late adolescent joints, indicating that operative treatment should be considered in active, late-adolescent patients with this injury. Increased forces on the MCL and medial meniscus after ACL transection suggested that rehabilitation protocols may need to focus on protecting these tissues.

Indexed as

Anterior Cruciate Ligament InjuriesJoint InstabilityAnimalsAnterior Cruciate LigamentBiomechanical PhenomenaCadaverFemaleHumansKnee JointMaleSwinekneesex factorstransection studies

Identifiers

PMID34964874
PMCPMC9842119
OpenAlexW4200078090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.