Evidence map›Paper›PMID 34964645›Full record

ArticleJournal of the American Chemical Society2022

Superfast Tetrazole-BCN Cycloaddition Reaction for Bioorthogonal Protein Labeling on Live Cells.

Gangam Srikanth Kumar, Stefano Racioppi, Eva Zurek, Qing Lin

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Fluorogenic Sydnones for Bioorthogonal Labeling of DNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Protein Modification via Bioorthogonal HS-BCN Ligation.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Not So Bioorthogonal Chemistry.Journal of the American Chemical Society · 2025
    Review
  7. Review
  8. A concise synthesis ofRSC advances · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gangam Srikanth KumarDepartment of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260-3000, United States.
Stefano RacioppiDepartment of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260-3000, United States.
Eva ZurekDepartment of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260-3000, United States.ORCID 0000-0003-0738-867X
Qing LinDepartment of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260-3000, United States.ORCID 0000-0002-9196-5718

Funding

Development and Applications of Bioorthogonal Chemistry: Equipment SupplementR35GM130307 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Qing Lin · 2019 to 2026
$3.6M
Acquisition of High Performance Data and Computing Infrastructure to Advance Biomedical ResearchS10OD024973 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FURLANI, THOMAS · 2019 to 2019
$1.0M
NIGMS NIH HHS R35 GM130307NIH HHS S10 OD024973
6 · The paper itself

Abstract

Here we report the design of a superfast bioorthogonal ligation reactant pair comprising a sterically shielded, sulfonated tetrazole and bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN). The design involves placing a pair of water-soluble

Indexed as

Cycloaddition ReactionTetrazolesBridged Bicyclo CompoundsHumansMolecular Structure1H-tetrazolebicyclo(6.1.0)nonyneBridged Bicyclo CompoundsTetrazoles

Identifiers

PMID34964645
PMCPMC8982153

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.