Evidence map›Paper›PMID 34964607›Full record

ArticleBiochemistry2022

Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.

Miles Sasha Dickinson, Sergei Pourmal, Meghna Gupta, Maxine Bi, Robert M Stroud

Abstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Structure reveals a regulation mechanism of plant outward-rectifying KProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. GORK KNature communications · 2025
    Article
  7. Article
  8. Voltage sensors.Molecular pharmacology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miles Sasha DickinsonDepartment of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.ORCID 0000-0002-8016-1570
Sergei PourmalDepartment of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.
Meghna GuptaDepartment of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.
Maxine BiDepartment of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.
Robert M StroudDepartment of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Molecular Basis for Transmembrane Conduction & SignalingR37GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 2007 to 2016
$4.7M
Research Training in Chemistry and Chemical BiologyT32GM145460 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason E Gestwicki · 2022 to 2026
$3.1M
Peroxisomal fatty acid metabolism in genetic and age-related disordersK99AG070271 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUPTA, MEGHNA · 2022 to 2023
$250k
NIA NIH HHS K99 AG070271NIGMS NIH HHS R01 GM024485NIGMS NIH HHS R37 GM024485NIGMS NIH HHS T32 GM008284NIGMS NIH HHS T32 GM145460
6 · The paper itself

Abstract

Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from

Indexed as

ArabidopsisArabidopsis ProteinsGene Expression Regulation, PlantIon ChannelsLipidsPotassiumPotassium ChannelsSoilArabidopsis ProteinsIon ChannelsLipidsPotassiumPotassium ChannelsSoil

Identifiers

PMID34964607
PMCPMC9931035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.