Evidence map›Paper›PMID 34964435›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022

Neurophysiological profiles of responders and nonresponders to hypoglossal nerve stimulation: a single-institution study.

Daiqi Wang, Oleg Modik, Joshua J Sturm, James Metkus, Rachel Oaks-Leaf, Adam Kaplan, Quan Ni, Maria Suurna

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Obstructive sleep apnea: a review for the orthodontist.Dental press journal of orthodontics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Daiqi WangDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.
Oleg ModikDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.
Joshua J SturmDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.
James MetkusDivision of Otolaryngology-Head and Neck Surgery, Stony Brook Medicine, Stony Brook, New York.
Rachel Oaks-LeafDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.
Adam KaplanInspire Medical Systems, Inc., Minneapolis, Minnesota.
Quan NiInspire Medical Systems, Inc., Minneapolis, Minnesota.
Maria SuurnaDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.
Weill Cornell Medicine · USInspire Medical Systems (United States) · USCornell University · USStony Brook Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesHypoglossal nerve stimulation (HGNS) is an effective alternative treatment for obstructive sleep apnea that acts by opening the airway via selective stimulation of nerve fibers that innervate tongue muscles that protrude (genioglossus) and stiffen the tongue (transverse and vertical) while avoiding nerve fibers that innervate tongue muscles that retract the tongue (styloglossus and hyoglossus). There remains a subset of postoperative patients who fail to adequately respond to HGNS, in some cases due to mixed activation of muscles that simultaneously protrude and retract the tongue. This study aims to characterize the relationship between neurophysiological data from individual tongue muscle activation during intraoperative electromyographic recordings and postoperative apnea-hypopnea index responses to HGNS.

methodsA single-institution review of 46 patients undergoing unilateral HGNS implantation for obstructive sleep apnea. Patients were separated into

resultsThe overall treatment success rate was 61% as determined by a postoperative apnea-hypopnea index < 20 events/h with a greater than 50% AHI reduction. We observed no statistically significant relationships between treatment response and individual muscle responses. However, we did note that increasing body mass index was correlated with worse postoperative responses.

conclusionsAlthough we noted a significant subgroup of clinical nonresponders to HGNS postoperatively, these patients were not found to exhibit significant inclusion of tongue retractors intraoperatively on neurophysiological analysis. Further research is needed to delineate additional phenotypic factors that may contribute to HGNS treatment responses. CITATION: Wang D, Modik O, Sturm JJ, et al. Neurophysiological profiles of responders and nonresponders to hypoglossal nerve stimulation: a single-institution study.

Indexed as

Electric Stimulation TherapySleep Apnea, ObstructiveFacial MusclesHumansHypoglossal NerveTonguehypoglossal nerve stimulationobstructive sleep apneasleep studysleep surgerystimulation settingsupper airway stimulation

Identifiers

PMID34964435
PMCPMC9059610
OpenAlexW4200580880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.