Evidence map›Paper›PMID 34964421›Full record

ArticleDrug delivery2022

Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy.

Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin, Jihui Tang, Xi Cao

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  4. Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Embracing cancer immunotherapy with manganese particles.Cellular oncology (Dordrecht, Netherlands) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bo LiDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Tingfei TanDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Weiwei ChuDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Ying ZhangDepartment of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yuanzi YeDepartment of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Shanshan WangDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Yan QinSchool of Pharmacy, Anhui Medical University, Hefei, China.
Jihui TangSchool of Pharmacy, Anhui Medical University, Hefei, China.
Xi CaoDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Anhui Medical University · CNState Administration of Traditional Chinese Medicine of the People's Republic of China · CNFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is one of the most common types of cancer in female patients with high morbidity and mortality. Multi-drug chemotherapy has significant advantages in the treatment of malignant tumors, especially in reducing drug toxicity, increasing drug sensitivity and reducing drug resistance. The objective of this research is to fabricate lipid nanoemulsions (LNs) for the co-delivery of PTX and docosahexaenoic acid (DHA) with folic acid (FA) decorating (PTX/DHA-FA-LNs), and investigate the anti-tumor activity of the PTX/DHA-FA-LNs against breast cancer both

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisCell Line, TumorCell SurvivalDose-Response Relationship, DrugDrug CarriersDrug LiberationEmulsionsFemaleFolic AcidHumansMCF-7 CellsMiceMice, Inbred BALB CMice, NudeAntineoplastic Agents, Phytogenicdocosahexaenoyl-paclitaxelDrug CarriersEmulsionsFolic AcidPaclitaxelbreast cancerdocosahexaenoic acid (DHA)folic acid (FA)lipid nanoemulsions (LNs)multi-drug chemotherapyPaclitaxel (PTX)

Identifiers

PMID34964421
PMCPMC8735879
OpenAlexW4200313591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.