Evidence map›Paper›PMID 34964351›Full record

ArticleACS biomaterials science & engineering2022

Zn-Mg-WC Nanocomposites for Bioresorbable Cardiovascular Stents: Microstructure, Mechanical Properties, Fatigue, Shelf Life, and Corrosion.

Zeyi Guan, Chase S Linsley, Shuaihang Pan, Gongcheng Yao, Benjamin M Wu, Daniel S Levi, Xiaochun Li

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Bioactive materials · 2025
    Article
  3. Article
  4. Article
  5. Experimental study on novel biodegradable Zn-Fe-Si alloys.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zeyi GuanDepartment of Mechanical & Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 48-121 Engineering IV, Los Angeles, California 90095, United States.ORCID 0000-0001-7448-9468
Chase S LinsleyDepartment of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, California 90095, United States.
Shuaihang PanDepartment of Mechanical & Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 48-121 Engineering IV, Los Angeles, California 90095, United States.ORCID 0000-0002-5312-992X
Gongcheng YaoDepartment of Materials Science & Engineering, Samueli School of Engineering, University of California, Los Angeles. 410 Westwood Plaza, 3111 Engineering V, Los Angeles, California 90095, United States.
Benjamin M WuDepartment of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, California 90095, United States.
Daniel S LeviDepartment of Pediatrics, Division of Cardiology, Children's Heart Center 330, UCLA Mattel Children's Hospital, Los Angeles. 200 Medical Plaza, Los Angeles, California 90095, United States.
Xiaochun LiDepartment of Mechanical & Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 48-121 Engineering IV, Los Angeles, California 90095, United States.ORCID 0000-0001-9176-7722
University of California, Los Angeles · USMattel Children's Hospital · US

Funding

Novel Zinc-Nanocomposite Materials for Pediatric Bioresorbable Cardiovascular StentsR01HL143465 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVI, DANIEL STEVEN, LI, XIAOCHUN · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL143465
6 · The paper itself

Abstract

Zinc (Zn) and Zn alloys have been studied as potential materials for bioresorbable stents (BRSs) in the last decade due to their favorable biodegradability and biocompatibility. However, most Zn alloys lack the necessary combination of strength, ductility, fatigue resistance, corrosion rate (CR), and thermal stability needed for such applications. In this study, nanoparticles made of tungsten carbide (WC) were successfully incorporated into Zn alloyed with 0.5 wt % magnesium (Mg) and evaluated for their suitability for BRS applications. Specifically, the resulting Zn-0.5Mg-WC nanocomposite's microstructure, mechanical properties, in vitro CR, and thermal stability were evaluated. The Zn-0.5Mg-WC nanocomposite had excellent mechanical strength [ultimate tensile strength (UTS) > 250 MPa], elongation to failure (>30%), and a suitable in vitro CR (∼0.02 mm/y) for this clinical application. Moreover, the Zn-0.5Mg-WC nanocomposite survived 10 million cycles of tensile loading (stress ratio,

Indexed as

MagnesiumNanocompositesAbsorbable ImplantsCorrosionMaterials TestingStentsZincMagnesiumZincbioresorbable stentmechanical propertymetal matrix nanocompositeZn alloys

Identifiers

PMID34964351
PMCPMC9310700
OpenAlexW4200558229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.