Evidence map›Paper›PMID 34964287›Full record

ArticleMicrobiologyOpen2021

Binding of the kringle-2 domain of human plasminogen to streptococcal PAM-type M-protein causes dissociation of PAM dimers.

Olawole Ayinuola, Yetunde A Ayinuola, Cunjia Qiu, Shaun W Lee, Victoria A Ploplis, Francis J Castellino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Olawole AyinuolaW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Yetunde A AyinuolaW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Cunjia QiuW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Shaun W LeeW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Victoria A PloplisW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Francis J CastellinoW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0003-0317-9539
University of Notre Dame · US

Funding

STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Plasminogen and Plasmin: Structure and FunctionR56HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 2022 to 2022
$743k
STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR37HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J · 1990 to 1999
–
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R37 HL013423NHLBI NIH HHS R56 HL013423
6 · The paper itself

Abstract

The direct binding of human plasminogen (hPg), via its kringle-2 domain (K2

Indexed as

KringlesAntigens, BacterialBacterial Outer Membrane ProteinsBinding SitesCarrier ProteinsHumansMolecular WeightPlasminogenProtein BindingProtein Conformation, alpha-HelicalProtein MultimerizationStreptococcus pyogenesStreptokinaseTemperatureThermodynamicsAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsPlasminogenstreptococcal M proteinStreptokinaseanalytical ultracentrifugationcircular dichroismhuman plasminogenisothermal calorimetrykringle domainsstreptococcal plasminogen binding M-protein

Identifiers

PMID34964287
PMCPMC8633249
OpenAlexW3215090378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.