ArticleAging medicine (Milton (N.S.W))2021
10-year frailty trajectory is associated with Alzheimer's dementia after considering neuropathological burden.
Article in Aging medicine (Milton (N.S.W)), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature.Journal of the American Geriatrics Society · 2026Pooled it
- Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study.The Journal of frailty & aging · 2026Article
- Frailty Status and Dysphagia Trajectory Among Hospitalized Nursing Home Residents With Advanced Dementia.Journal of the American Medical Directors Association · 2025Article
- Exploring Frailty Status and Blood Biomarkers: A Multidimensional Approach to Alzheimer's Diagnosis.Geriatrics (Basel, Switzerland) · 2025Article
- Mapping the Final Journey: End-Of-Life Frailty Trajectories and Cause of Death.Journal of the American Geriatrics Society · 2025Article
- Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.Acta neuropathologica communications · 2025Article
- Frailty in motion: Amnestic mild cognitive impairment and Alzheimer's disease cohorts display heterogeneity in multimorbidity classification and longitudinal transitions.Journal of Alzheimer's disease : JAD · 2025Article
- Frailty trajectories preceding dementia: an individual-level analysis of four cohort studies in the United States and United Kingdom.Research square · 2024Article
- Associations of Orthostatic Hypotension and Frailty With Dementia and Mortality in Older Adults: A Population-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Loneliness Predicts Progression of Frailty in Married and Widowed, but Not Unmarried Community Dwelling Older Adults.The Journal of frailty & aging · 2024Article
- Comparison of Frailty and Chronological Age as Determinants of the Murine Gut Microbiota in an Alzheimer's Disease Mouse Model.Microorganisms · 2023Article
- Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults.Immunity & ageing : I & A · 2023Article
- Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- The vital need for action against the social determinants of frailty.Aging medicine (Milton (N.S.W)) · 2022Article
- Circulating Cell-Free Genomic DNA Is Associated with an Increased Risk of Dementia and with Change in Cognitive and Physical Function.Journal of Alzheimer's disease : JAD · 2022Article
- To understand the diabetes-dementia association, frailty may prove more fruitful than neuropathology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- 10-year frailty trajectory is associated with Alzheimer's dementia after considering neuropathological burden.Aging medicine (Milton (N.S.W)) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
main problemFrailty is an established risk factor for cognitive decline and Alzheimer's disease. Few studies have examined the longitudinal relationship between frailty and cognition.
methodsParticipants of Rush Memory and Aging project (
resultsAt baseline the mean frailty index = 0.24 ± 0.12 and increased at rate of 0.026 or ~1 deficit per year. At death, 27.7% of the sample had MCI, and 38.6% had dementia. Frailty trajectories were significantly steeper among those individuals who were ultimately diagnosed as clinically impaired prior to death, even after controlling for age, sex, education, and neuropathological index.
conclusionsFindings suggest a strong link between health status (frailty index) and dementia, even after considering neuropathology. Frailty trajectories were associated with risk for MCI and dementia, underscoring the importance of addressing frailty to manage dementia risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.