Evidence map›Paper›PMID 34963742›Full record

ReviewWorld journal of gastroenterology2021

Gut microbiome in allogeneic hematopoietic stem cell transplantation and specific changes associated with acute graft

Quentin Le Bastard, Patrice Chevallier, Emmanuel Montassier

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Quentin Le BastardDepartment of Emergency Medicine, Nantes University Hospital, Nantes 44093, France.
Patrice ChevallierDepartment of Hematology, Nantes University Hospital, Nantes 44093, France.
Emmanuel MontassierDepartment of Emergency Medicine, Nantes University Hospital, Nantes 44093, France. emmanuel.montassier@chu-nantes.fr.
Centre Hospitalier Universitaire de Nantes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (aHSCT) is a standard validated therapy for patients suffering from malignant and nonmalignant hematological diseases. However, aHSCT procedures are limited by potentially life-threatening complications, and one of the most serious complications is acute graft-versus-host disease (GVHD). During the last decades, DNA sequencing technologies were used to investigate relationship between composition or function of the gut microbiome and disease states. Even if it remains unclear whether these microbiome alterations are causative or secondary to the presence of the disease, they may be useful for diagnosis, prevention and therapy in aHSCT recipients. Here, we summarized the most recent findings of the association between human gut microbiome changes and acute GVHD in patients receiving aHSCT.

Indexed as

Gastrointestinal MicrobiomeGraft vs Host DiseaseHematologic DiseasesHematopoietic Stem Cell TransplantationMicrobiotaHumansAcute graft vs host diseaseAllogeneic hematopoietic stem cell transplantationBiomarkersCompositionDNA sequencing technologiesFunctionGut microbiomeTransplants

Identifiers

PMID34963742
PMCPMC8661383
OpenAlexW3217237907

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.