Evidence map›Paper›PMID 34963727›Full record

ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2021

A Real-world Study on Prescription Pattern of Fosfomycin in Critical Care Patients.

Kapil G Zirpe, Yatin Mehta, Rahul Pandit, Rajesh Pande, Abhijit M Deshmukh, Saiprasad Patil, Sagar Bhagat, Hanmant Barkate

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kapil G ZirpeDepartment of Neuro Trauma Unit, Grant Medical Foundation, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0002-8140-727X
Yatin MehtaInstitute of Critical Care and Anesthesia, Medanta-The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-0888-4774
Rahul PanditDepartment of Intensive Care, Fortis, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0002-5846-3708
Rajesh PandeDepartment of Critical Care Medicine, BLK Super Speciality Hospital, Delhi, India.ORCID https://orcid.org/0000-0002-0149-727X
Abhijit M DeshmukhDepartment of Neuro Trauma Stroke Unit, Grant Medical Foundation's Ruby Hall Clinic, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0001-5602-291X
Saiprasad PatilDepartment of Global Medical Affairs, Glenmark Pharmaceutical Ltd, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0002-4937-3188
Sagar BhagatGlenmark Pharmaceutical Ltd, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0002-0488-9359
Hanmant BarkateDepartment of Global Medical Affairs, Glenmark Pharmaceutical Ltd, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0003-4346-9194
Ruby Hall Clinic · INBLK Super Speciality Hospital · INGlenmark Pharmaceuticals (India) · INGrant Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study presents a real-world scenario for prescription pattern, efficacy, and safety data on the current clinical use of intravenous fosfomycin in critically ill patients in Indian settings. PATIENTS AND

methodsThis was a retrospective cohort study conducted for a period of 10 months among critically ill patients admitted to hospital's critical care unit. The primary objective of the study was to analyze the prescription pattern of intravenous fosfomycin, and the secondary objective was to evaluate the safety profile and patient outcomes.

resultsA total of 309 patients were enrolled, and they were diagnosed with bacteremia (45.3%), pneumonia (15.85%), septic shock (14.24%), and urinary tract infections (UTI) (13.91%). The average dose of fosfomycin given was 11.7 ± 4.06 gm/day. The average duration of the therapy was 4.85 ± 3.59 days with a median duration of 4 days. Fosfomycin was given at 8 hourly dosing frequency to maximum (45.6%) cases. Hypokalemia was the most observed adverse event. The overall survival was seen in 55% of patients.

conclusionOur data suggest that UTI, infection caused by HOW TO CITE THIS ARTICLE: Zirpe KG, Mehta Y, Pandit R, Pande R, Deshmukh AM, Patil S,

Indexed as

Critically ill adultsFosfomycinRetrospective study

Identifiers

PMID34963727
PMCPMC8664030
OpenAlexW3198733571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.