Evidence map›Paper›PMID 34963651›Full record

ArticleNeuroImage2022

Context-specific activations are a hallmark of the neural basis of individual differences in general executive function.

Andrew E Reineberg, Marie T Banich, Tor D Wager, Naomi P Friedman

Abstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew E ReinebergDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States. Electronic address: andrew.reineberg@colorado.edu.
Marie T BanichDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States; Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, United States.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States.
Naomi P FriedmanDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States.

Funding

Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5M
14/21 ABCD-USA Consortium: Research Project Site at CU BoulderU01DA051018 · NIDA · UNIVERSITY OF COLORADO · PI Marie T Banich, Naomi P. Friedman · 2020 to 2026
$11.4M
Neural Substrates of Executive Function: An fMRI Twin StudyR01MH063207 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI FRIEDMAN, NAOMI P. · 2001 to 2018
$6.5M
Brain and Genetic Predictors of Individual Differences in Pain and Placebo AnalgesiaR01DA046064 · NIDA · UNIVERSITY OF COLORADO · PI FRIEDMAN, NAOMI P., WAGER, TOR D. · 2018 to 2022
$3.2M
Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
Executive Functions and Self-Regulation: A Twin StudyR56MH063207 · NIMH · UNIVERSITY OF COLORADO · PI HEWITT, JOHN K. · 2007 to 2007
$490k
NIA NIH HHS R01 AG046938NIDA NIH HHS R01 DA042742NIDA NIH HHS R01 DA046064NIDA NIH HHS U01 DA051018NIMH NIH HHS R01 MH063207NIMH NIH HHS R56 MH063207
6 · The paper itself

Abstract

Common executive functioning (cEF) is a domain-general factor that captures shared variance in performance across diverse executive function tasks. To investigate the neural mechanisms of individual differences in cEF (e.g., goal maintenance, biasing), we conducted the largest fMRI study of multiple executive tasks to date (N = 546). Group average activation during response inhibition (antisaccade task), working memory updating (keep track task), and mental set shifting (number-letter switch task) overlapped in classic cognitive control regions. However, there were no areas across tasks that were consistently correlated with individual differences in cEF ability. Although similar brain areas are recruited when completing different executive function tasks, activation levels of those areas are not consistently associated with better performance. This pattern is inconsistent with a simple model in which higher cEF is associated with greater or less activation of a set of control regions across different task contexts; however, it is potentially consistent with a model in which individual differences in cEF primarily depend on activation of domain-specific targets of executive function. Brain features that explain commonalities in executive function performance across tasks remain to be discovered.

Indexed as

Brain MappingInhibition, PsychologicalAdultBiological Variation, PopulationCerebral CortexExecutive FunctionFemaleHumansIndividualityMagnetic Resonance ImagingMaleMemory, Short-TermPsychomotor Performance

Identifiers

PMID34963651
PMCPMC8844140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.