Evidence map›Paper›PMID 34963501›Full record

ArticleBioelectronic medicine2021

Robotic Kinematic measures of the arm in chronic Stroke: part 1 - Motor Recovery patterns from tDCS preceding intensive training.

Caio B Moretti, Dylan J Edwards, Taya Hamilton, Mar Cortes, Avrielle Rykman Peltz, Johanna L Chang, Alexandre C B Delbem, Bruce T Volpe, Hermano I Krebs

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectronic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01726673 phase2completednot on this map

Effects of Transcranial Direct Current Stimulation Paired With Robotic Arm Therapy on Recovery of Upper Extremity Motor Function in Stroke Patients

TypeinterventionalSponsorNorthwell HealthRan2012 to 2018Enrolled54ConditionsStrokeArmsTranscranial Direct Current Stimulation (tDCS), Placebo sham
NCT03562663 nacompletednot on this map

Transcranial Direct Current Stimulation and Robotic Training in Chronic Stroke

TypeinterventionalSponsorBurke Medical Research InstituteRan2012 to 2016Enrolled82ConditionsChronic StrokeArmsTranscranial direct current stimulation, Upper extremity robotics
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Caio B MorettiDepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, office 3-137, Cambridge, MA, 02139, USA.
Dylan J EdwardsMoss Rehabilitation Research Institute, 60 Township Line Rd, Elkins Park, PA, 19027, USA.
Taya HamiltonDepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, office 3-137, Cambridge, MA, 02139, USA.
Mar CortesIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA.
Avrielle Rykman PeltzRehabologym, 90 N Broadway, Irvington, NY, 10533, USA.
Johanna L ChangFeinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA.
Alexandre C B DelbemUniversidade de Sao Paulo, Avenida Trabalhador Saocarlense - 400, Sao Carlos, SP, Brazil.
Bruce T VolpeFeinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA.
Hermano I KrebsDepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, office 3-137, Cambridge, MA, 02139, USA. hikrebs@mit.edu.
Massachusetts Institute of Technology · USFeinstein Institute for Medical Research · USIcahn School of Medicine at Mount Sinai · USMoss Rehabilitation Hospital · USUniversidade de São Paulo · BR

Funding

Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD069776FAPESP 2019/06551-5MISTI-Brazil, Massachusetts Institute of Technology 2160632NICHD NIH HHS R01 HD069776
6 · The paper itself

Abstract

backgroundEffectiveness of robotic therapy and transcranial direct current stimulation is conventionally assessed with clinical measures. Robotic metrics may be more objective and sensitive for measuring the efficacy of interventions on stroke survivor's motor recovery. This study investigated if robotic metrics detect a difference in outcomes, not seen in clinical measures, in a study of transcranial direct current stimulation (tDCS) preceding robotic therapy. Impact of impairment severity on intervention response was also analyzed to explore optimization of outcomes by targeting patient sub-groups.

methodsThis 2020 study analyzed data from a double-blind, sham-controlled, randomized multi-center trial conducted from 2012 to 2016, including a six-month follow-up. 82 volunteers with single chronic ischemic stroke and right hemiparesis received anodal tDCS or sham stimulation, prior to robotic therapy. Robotic therapy involved 1024 repetitions, alternating shoulder-elbow and wrist robots, for a total of 36 sessions. Shoulder-elbow and wrist kinematic and kinetic metrics were collected at admission, discharge, and follow-up.

resultsNo difference was detected between the tDCS or sham stimulation groups in the analysis of robotic shoulder-elbow or wrist metrics. Significant improvements in all metrics were found for the combined group analysis. Novel wrist data showed smoothness significantly improved (P < ·001) while submovement number trended down, overlap increased, and interpeak interval decreased. Post-hoc analysis showed only patients with severe impairment demonstrated a significant difference in kinematics, greater for patients receiving sham stimulation.

conclusionsRobotic data confirmed results of clinical measures, showing intensive robotic therapy is beneficial, but no additional gain from tDCS. Patients with severe impairment did not benefit from the combined intervention. Wrist submovement characteristics showed a delayed pattern of motor recovery compared to the shoulder-elbow, relevant to intensive intervention-related recovery of upper extremity function in chronic stroke.

trial registrationhttp://www.clinicaltrials.gov . Actual study start date September 2012. First registered on 15 November 2012. Retrospectively registered. Unique identifiers: NCT01726673 and NCT03562663 .

Indexed as

KinematicsOutcome measuresRoboticsStroketDCS

Identifiers

PMID34963501
PMCPMC8715636
OpenAlexW4200412172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.