Evidence map›Paper›PMID 34963499›Full record

ArticleJournal of nanobiotechnology2021

Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined cancer therapy.

Xiaoli Zhang, Yi Lu, Die Jia, Wei Qiu, Xianbin Ma, Xingliang Zhang, Zhigang Xu, Feiqiu Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoli Zhang *Pediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, People's Republic of China.
Yi Lu *School of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing, 400715, People's Republic of China.
Die JiaSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing, 400715, People's Republic of China.
Wei QiuSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing, 400715, People's Republic of China.
Xianbin MaSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing, 400715, People's Republic of China.
Xingliang ZhangPediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, People's Republic of China. xingliang_zhang@163.com.
Zhigang XuPediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, People's Republic of China. zgxu@swu.edu.cn.ORCID http://orcid.org/0000-0003-1805-5061
Feiqiu WenPediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, People's Republic of China. fwen62@163.com.
Shenzhen Children's Hospital · CNSouthwest University · CN

Funding

National Natural Science Foundation of China 51703187
6 · The paper itself

Abstract

backgroundThe complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop innovative drug delivery system based on nano-strategies.

resultIn this study, an intracellular acidity-responsive polymeric metal organic framework nanoparticle (denoted as DIMP) has been constructed, which can co-deliver the chemotherapy agent of doxorubicin (DOX) and phototherapy agent of indocyanine green (ICG) for breast carcinoma theranostics. Specifically, DIMP possesses a suitable and stable nanometer size and can respond to the acidic microenvironment in cells, thus precisely delivering drugs into target tumor sites and igniting the biological reactions towards cell apoptosis. Following in vivo and in vitro results showed that DIMP could be effectively accumulated in tumor sites and induced powerful immunogenic cell death (ICD) effect.

conclusionThe designed DIMP displayed its effectiveness in combined photo-chemotherapy with auxiliary of ICD effect under a multimodal imaging monitor. Thus, the present MOF-based strategy may offer a potential paradigm for designing drug-delivery system for image-guided synergistic tumor therapy.

Indexed as

AnimalsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorCombined Modality TherapyDoxorubicinDrug Delivery SystemsFemaleImmunogenic Cell DeathIndocyanine GreenMetal-Organic FrameworksMiceMultimodal ImagingNanoparticlesPhototherapyTumor MicroenvironmentAntineoplastic AgentsDoxorubicinIndocyanine GreenMetal-Organic FrameworksImmunogenic cell deathMulti-modal imagingNanoreactorSynergistic therapyTumor-specific activatable

Identifiers

PMID34963499
PMCPMC8715615
OpenAlexW4200201803

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.