Evidence map›Paper›PMID 34963308›Full record

ArticleCirculation. Heart failure2022

Invasive Right Ventricular Pressure-Volume Analysis: Basic Principles, Clinical Applications, and Practical Recommendations.

Michael I Brener, Amirali Masoumi, Vivian G Ng, Khodr Tello, Marcelo B Bastos, William K Cornwell, Steven Hsu, Ryan J Tedford, Philipp Lurz, Karl-Philipp Rommel and 14 more

Abstract read
In one paragraph

Article in Circulation. Heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Right Heart Diastology, Where Are We Now?Circulation research · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bridging the Gap: Exploring Right Ventricular-Pulmonary Artery Coupling in Acute Coronary syndrome-A Pilot Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Right ventricular pressure-volume loop analysis in congenital heart disease.International journal of cardiology. Congenital heart disease · 2025
    Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Michael I BrenerDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).ORCID 0000-0002-2606-055X
Amirali MasoumiDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).
Vivian G NgDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).
Khodr TelloDepartment of Internal Medicine, Justus Liebig Universitat Giessen, Germany (K.T.).ORCID 0000-0002-5557-623X
Marcelo B BastosDepartment of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (M.B.B., A.J.M.V.D.E., N.M.V.M.).ORCID 0000-0003-2269-8983
William K CornwellDivision of Cardiology, University of Colorado Anschutz Medical Campus, Aurora (W.K.C.).ORCID 0000-0002-0863-1187
Steven HsuDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.H.).ORCID 0000-0002-8384-2638
Ryan J TedfordDivision of Cardiology, Medical University of South Carolina, Charleston (R.J.T.).ORCID 0000-0001-9045-7722
Philipp LurzDivision of Cardiology, Heart Center, University of Leipzig, Germany (P.L., K.-P.R., K.-P.K.).ORCID 0000-0002-5993-4487
Karl-Philipp RommelDivision of Cardiology, Heart Center, University of Leipzig, Germany (P.L., K.-P.R., K.-P.K.).ORCID 0000-0002-2901-8138
Karl-Patrik KresojaDivision of Cardiology, Heart Center, University of Leipzig, Germany (P.L., K.-P.R., K.-P.K.).ORCID 0000-0002-8616-6751
Sherif F NaguehSection of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, TX (S.F.N.).ORCID 0000-0002-4911-8056
Manreet K KanwarCardiovascular Institute, Alleghany Health Network, Pittsburgh, PA (M.K.K.).ORCID 0000-0002-7280-5268
Navin K KapurCardiovascular Center and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (N.K.K.).ORCID 0000-0002-8302-6796
Gurumurthy HiremathDivision of Pediatric Cardiology, University of Minnesota Masonic Children's Hospital, Minneapolis (G.H.).ORCID 0000-0001-6686-896X
Mohammad SarrafDivision of Cardiology, Mayo Clinic, Rochester, MN (M.S.).
Antoon J M Van Den EndenDepartment of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (M.B.B., A.J.M.V.D.E., N.M.V.M.).
Nicolas M Van MieghemDepartment of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (M.B.B., A.J.M.V.D.E., N.M.V.M.).ORCID 0000-0002-2732-1205
Paul M HeerdtDivision of Anesthesiology, Yale University School of Medicine, New Haven, CT (P.M.H.).
Rebecca T HahnDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).ORCID 0000-0003-1342-9191
Susheel K KodaliDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).
Gabriel T SayerDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).ORCID 0000-0003-1701-1593
Nir UrielDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).ORCID 0000-0003-2301-3587
Daniel BurkhoffDivision of Cardiology, Columbia University Medical Center, New York, NY (M.I.B., A.M., V.G.N., R.T.H., S.K.K., G.T.S., N.U., D.B.).ORCID 0000-0003-3995-2466

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Mechanisms and treatment of right ventricular sarcomere dysfunction in scleroderma-associated pulmonary arterial hypertensionK23HL146889 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HSU, STEVEN · 2019 to 2023
$886k
NCATS NIH HHS UL1 TR001873NHLBI NIH HHS K23 HL146889NHLBI NIH HHS T32 HL007343
6 · The paper itself

Abstract

Right ventricular pressure-volume (PV) analysis characterizes ventricular systolic and diastolic properties independent of loading conditions like volume status and afterload. While long-considered the gold-standard method for quantifying myocardial chamber performance, it was traditionally only performed in highly specialized research settings. With recent advances in catheter technology and more sophisticated approaches to analyze PV data, it is now more commonly used in a variety of clinical and research settings. Herein, we review the basic techniques for PV loop measurement, analysis, and interpretation with the aim of providing readers with a deeper understanding of the strengths and limitations of PV analysis. In the second half of the review, we detail key scenarios in which right ventricular PV analysis has influenced our understanding of clinically relevant topics and where the technique can be applied to resolve additional areas of uncertainty. All told, PV analysis has an important role in advancing our understanding of right ventricular physiology and its contribution to cardiovascular function in health and disease.

Indexed as

Heart FailureHeart VentriclesHemodynamicsHumansStroke VolumeVentricular Dysfunction, RightVentricular Function, LeftVentricular Function, RightVentricular Pressureheart failurehemodynamicspulmonary circulationventricular function, right

Identifiers

PMID34963308
PMCPMC8766922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.