SynthesisKorean journal of anesthesiology2022
Efficacy of perineural versus intravenous dexamethasone in prolonging the duration of analgesia when administered with peripheral nerve blocks: a systematic review and meta-analysis.
Synthesis in Korean journal of anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Role of articaine and perineural dexamethasone in prolonging postoperative analgesia in mandibular third molar surgery: A comparative analysis.Medicina oral, patologia oral y cirugia bucal · 2026Trial
- Trial
- Dexamethasone vs. Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Total Knee Arthroplasty: A Randomized Double-Blind Controlled Trial.Journal of clinical medicine · 2026Article
- Musculoskeletal ultrasound-guided cellular therapy: Current applications and future directions in skeletal muscle regeneration.Iranian journal of basic medical sciences · 2026Review
- Investigating Why Comparing Intravenous and Perineural Dexamethasone Is Scientifically Unfounded.Cureus · 2025Article
- Use of Dexamethasone via Two Methods in PENG Block for Patients Undergoing Femoral Fracture Surgery: A Prospective Observational Study.Journal of clinical medicine · 2025Article
- Impact of Corticosteroids in Suprascapular Nerve Block on Pain and Function in Chronic Rotator Cuff Disease: A Retrospective, Observational, Longitudinal, Analytical Cohort Study.Medical sciences (Basel, Switzerland) · 2025Observational
- Balancing benefit and risk: clinical considerations in the use of acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone for perioperative multimodal analgesia.The Korean journal of pain · 2025Review
- Perineural dexamethasone: neurotoxicity or neuroprotection? A systematic review of preclinical evidence.Journal of anesthesia, analgesia and critical care · 2025Review
- Prolonging peripheral nerve block duration: Current techniques and future perspectives.Acta anaesthesiologica Scandinavica · 2025Article
- A comparative evaluation of the effect of addition of 8 mg dexamethasone to 2% lignocaine with adrenaline in mandibular third molar surgery: a split mouth randomised double blind study.Frontiers in oral health · 2024Article
- The Use of Peripheral Nerve Block and Intra-articular Steroid Injection for Pain Management in an Adolescent with Hutchinson-Gilford Progeria Syndrome: A Case Report.Acta medica Philippina · 2024Article
- [Rebound pain-From definition to treatment].Die Anaesthesiologie · 2022Review
- A randomized controlled trial evaluating the efficacy of combined dexamethasone and dexmedetomidine as adjuvants to ropivacaine in adductor canal block for postoperative analgesia in total knee arthroplasty.Journal of anaesthesiology, clinical pharmacologyArticle
- Fascial plane blocks for postoperative pain management after fast-track total knee arthroplasty: A narrative review.Saudi journal of anaesthesiaReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerineural dexamethasone has been regarded as a promising adjunct for prolonging the duration of nerve blocks. However, it is uncertain whether its effects are due to local effects on the nerves or from systemic absorption. This systematic review aimed to compare the duration of postoperative analgesia associated with perineural versus intravenous dexamethasone as an adjunct to peripheral nerve blocks.
methodsA total of 2,216 relevant academic articles were identified after a comprehensive search of PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov from 1967 until 2020. All randomized controlled trials that compared perineural and intravenous dexamethasone as adjuncts to peripheral nerve limb blocks were included.
resultsFifteen randomized controlled trials (1,467 cases; 738 perineural dexamethasone, 729 intravenous dexamethasone) were eligible. The primary outcome (duration of analgesia) was significantly longer in the perineural than in the intravenous dexamethasone group (mean difference [MD]: 2.72 h, 95% CI [1.42, 4.01], P < 0.001). Perineural dexamethasone was also found to prolong the sensory block (MD: 3.45 h, 95% CI [1.36, 5.54], P = 0.001) and lower 24 h postoperative pain scores (MD: -0.74 h, 95% CI [-1.40, -0.07], P = 0.03).
conclusionsThis review confirms the greater efficacy of perineural compared to intravenous dexamethasone in prolonging the analgesic duration of peripheral nerve blocks. However, the extent of prolongation was small and may not represent a clinically meaningful difference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.