Evidence map›Paper›PMID 34963066›Full record

ArticleCell chemical biology2022

Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.

Tim M G MacKenzie, Fayal Abderemane-Ali, Catherine E Garrison, Daniel L Minor, J Du Bois

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in pharmacology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tim M G MacKenzieDepartment of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA 94305, USA.
Fayal Abderemane-AliCardiovascular Research Institute, University of California, San Francisco, Box 3122, 555 Mission Bay Boulevard South, Rm. 452Z, San Francisco, CA 94158-9001, USA.
Catherine E GarrisonDepartment of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA 94305, USA.
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, Box 3122, 555 Mission Bay Boulevard South, Rm. 452Z, San Francisco, CA 94158-9001, USA; Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158-9001, USA; California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94158-9001, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94158-9001, USA; Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: daniel.minor@ucsf.edu.
J Du BoisDepartment of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA 94305, USA. Electronic address: jdubois@stanford.edu.
Stanford University · USQB3 · USUniversity of California, San Francisco · US

Funding

Structure and function of voltage-gated calcium channelsR01HL080050 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2005 to 2026
$9.8M
Structural Studies of Ion Channel Assembly and Signaling ComplexesR01DC007664 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2005 to 2026
$8.2M
Reaction Design for the Synthesis of Neuroactive AgentsR01NS045684 · NINDS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2003 to 2011
$3.0M
Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2M
NHLBI NIH HHS R01 HL080050NIDCD NIH HHS R01 DC007664NIGMS NIH HHS T32 GM120007NINDS NIH HHS R01 NS045684
6 · The paper itself

Abstract

Voltage-gated sodium channels (Na

Indexed as

BatrachotoxinsVoltage-Gated Sodium ChannelsEstersSodiumBatrachotoxinsEstersSodiumVoltage-Gated Sodium ChannelsbatrachotoxinelectrophysiologyNa(V) fast inactivationNa(V) slow inactivationvoltage-gated sodium channels (Na(V))

Identifiers

PMID34963066
PMCPMC9035044
OpenAlexW4225713332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.