ArticlePlant physiology2022
Deficiency in flavonoid biosynthesis genes CHS, CHI, and CHIL alters rice flavonoid and lignin profiles.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 61 citations in OpenAlex.
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- Integrated multi-omics elucidates StAN1 as a key regulator reprogramming flavonoid partitioning and co-regulatory networks in potato tubers.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Metabolomics and Transcriptomic Analysis Revealed the Response Mechanism of Maize to Saline-Alkali Stress.Plant biotechnology journal · 2025Article
- Physiological and Molecular Responses of Seed Germination to Irrigating-Sowing in Drought-Stressed Foxtail Millet (Plants (Basel, Switzerland) · 2025Article
- Analysis of Pigmentation Changes in Bracts ofBiology · 2025Article
- Genome-Wide Analysis and Screening of Uridine Diphosphate-Glycosyltransferase Family Genes Involved in Lignin/Flavonoid Glycosylation and Stress Response inPlants (Basel, Switzerland) · 2025Article
- Transcriptomic Comparison of Rice lncRNAs in Response to Feeding by Brown Planthopper Populations with Different Virulence.International journal of molecular sciences · 2025Article
- Modulation of morphogenesis and metabolism by plant cell biomechanics: from model plants to traditional herbs.Horticulture research · 2025Article
- Selection of chromosome segment substitution lines with reduced grain chalkiness without yield penalty in rice.Breeding science · 2025Article
- Advances and Future Prospects of Pigment Deposition in Pigmented Rice.Plants (Basel, Switzerland) · 2025Review
- Transcriptome analysis of rice resistant and susceptible near-isogenic lines in response to infection byFrontiers in plant science · 2025Article
- Identification of chalcone isomerase family genes and roles ofFrontiers in plant science · 2025Article
- Metabolomics Combined with Transcriptomics Analysis Reveals the Regulation of Flavonoids in the Leaf Color Change ofInternational journal of molecular sciences · 2024Article
- Integrated Metabolomics and Transcriptomics Provide Key Molecular Insights into Floral Stage-Driven Flavonoid Pathway in Safflower.International journal of molecular sciences · 2024Article
- Comprehensive transcriptome analysis of Asparagus officinalis in response to varying levels of salt stress.BMC plant biology · 2024Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin is a complex phenylpropanoid polymer deposited in the secondary cell walls of vascular plants. Unlike most gymnosperm and eudicot lignins that are generated via the polymerization of monolignols, grass lignins additionally incorporate the flavonoid tricin as a natural lignin monomer. The biosynthesis and functions of tricin-integrated lignin (tricin-lignin) in grass cell walls and its effects on the utility of grass biomass remain largely unknown. We herein report a comparative analysis of rice (Oryza sativa) mutants deficient in the early flavonoid biosynthetic genes encoding CHALCONE SYNTHASE (CHS), CHALCONE ISOMERASE (CHI), and CHI-LIKE (CHIL), with an emphasis on the analyses of disrupted tricin-lignin formation and the concurrent changes in lignin profiles and cell wall digestibility. All examined CHS-, CHI-, and CHIL-deficient rice mutants were largely depleted of extractable flavones, including tricin, and nearly devoid of tricin-lignin in the cell walls, supporting the crucial roles of CHS and CHI as committed enzymes and CHIL as a noncatalytic enhancer in the conserved biosynthetic pathway leading to flavone and tricin-lignin formation. In-depth cell wall structural analyses further indicated that lignin content and composition, including the monolignol-derived units, were differentially altered in the mutants. However, regardless of the extent of the lignin alterations, cell wall saccharification efficiencies of all tested rice mutants were similar to that of the wild-type controls. Together with earlier studies on other tricin-depleted grass mutant and transgenic plants, our results reflect the complexity in the metabolic consequences of tricin pathway perturbations and the relationships between lignin profiles and cell wall properties.
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