Evidence map›Paper›PMID 34962605›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2021

New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger.

M V Kondashevskaya, M V Komel'kova, V E Tseilikman, O B Tseilikman, K A Artem'yeva, V V Aleksankina, M N Boltovskaya, A P Sarapul'tsev, P N Popkov, M V Chereshneva and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

M V KondashevskayaAvtsyn Research Institute of Human Morphology, 117418, Moscow, Russia. marivladiko@mail.ru.
M V Komel'kovaSouth Ural State University, 454080, Chelyabinsk, Russia.
V E TseilikmanSouth Ural State University, 454080, Chelyabinsk, Russia.
O B TseilikmanSouth Ural State University, 454080, Chelyabinsk, Russia.
K A Artem'yevaAvtsyn Research Institute of Human Morphology, 117418, Moscow, Russia.
V V AleksankinaAvtsyn Research Institute of Human Morphology, 117418, Moscow, Russia.
M N BoltovskayaAvtsyn Research Institute of Human Morphology, 117418, Moscow, Russia.
A P Sarapul'tsevSouth Ural State University, 454080, Chelyabinsk, Russia.
P N PopkovSouth Ural State Medical University, 454092, Chelyabinsk, Russia.
M V ChereshnevaInstitute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, 620049, Yekaterinburg, Russia.
V A ChereshnevInstitute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, 620049, Yekaterinburg, Russia.
Research Institute of Human Morphology · RUInstitute of Immunology and Physiology · RUSouth Ural State University · RUChelyabinsk State Medical Academy · RUChelyabinsk State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the first time in modeling posttraumatic stress disorder (PTSD), we have described the morphofunctional state of adrenal glands in Wistar rats resistant and sensitive to predator stress (rodent fear of the predator). Despite the evident signs of adrenal dysfunction in both phenotypes, we have discovered the thickening of undifferentiated cell zone and high indices of functional activity of stem cells in resistant animals, suggesting ample adaptation. The most important data demonstrate the direct relationship between the reduction of corticosterone and testosterone levels and adrenal dysfunction in PTSD models. The study results allow considering the adrenal stem cells as potential therapeutic targets.

Indexed as

Stress Disorders, Post-TraumaticAnimalsCorticosteroneDisease Models, AnimalRatsRats, WistarStress, PsychologicalCorticosteroneadrenal stem cellsmorphofunctional characteristics of the adrenal glandspost-traumatic stress disorderstress resistanceWistar rats

Identifiers

PMID34962605
PMCPMC8713144
OpenAlexW4200064294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.