ArticleAngewandte Chemie (International ed. in English)2022
Discrete Stacked Dimers of Aromatic Oligoamide Helices.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Chalcogen bonding-directed photoresponsive helix from azo-fused H-bonded arylamide foldamers.Chemical science · 2026Article
- Aromatic residue-rich amino-terminal segments of temporin L self-assemble into collagen-mimetic peptides with cell-adhesion properties.The Journal of biological chemistry · 2026Article
- Design of an abiotic unimolecular three-helix bundle.Chemical science · 2025Article
- Visible-Light Driven Control Over Triply and Quadruply Hydrogen-Bonded Supramolecular Assemblies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Controlling aromatic helix dimerization in water by tuning charge repulsions.Chemical science · 2023Article
- Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Discrete Stacked Dimers of Aromatic Oligoamide Helices.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
4 authors.
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Abstract
Tight binding was observed between the C-terminal cross section of aromatic oligoamide helices in aqueous solution, leading to the formation of discrete head-to-head dimers in slow exchange on the NMR timescale with the corresponding monomers. The nature and structure of the dimers was evidenced by 2D NOESY and DOSY spectroscopy, mass spectrometry and X-ray crystallography. The binding interface involves a large hydrophobic aromatic surface and hydrogen bonding. Dimerization requires that helices have the same handedness and the presence of a C-terminal carboxy function. The protonation state of the carboxy group plays a crucial role, resulting in pH dependence of the association. Dimerization is also influenced by neighboring side chains and can be programmed to selectively produce heteromeric aggregates.
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