Evidence map›Paper›PMID 34961895›Full record

ArticlePurinergic signalling2022

Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity.

Julia Hesse, Mona K Rosse, Bodo Steckel, Bernhard Blank-Landeshammer, Svenja Idel, Yvonne Reinders, Albert Sickmann, Norbert Sträter, Jürgen Schrader

Open access · hybridAbstract read
In one paragraph

Article in Purinergic signalling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Julia HesseDepartment of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.ORCID 0000-0001-8555-259X
Mona K RosseDepartment of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.
Bodo SteckelDepartment of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.
Bernhard Blank-LandeshammerLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Svenja IdelLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Yvonne ReindersLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Albert SickmannLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Norbert SträterInstitute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.ORCID 0000-0002-2001-0500
Jürgen SchraderDepartment of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany. schrader@uni-duesseldorf.de.ORCID 0000-0002-7742-2768
Düsseldorf University Hospital · DELeibniz Institute for Analytical Sciences - ISAS · DELeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD73-derived adenosine plays a major role in damage-induced tissue responses by inhibiting inflammation. Damage-associated stimuli, such as hypoxia and mechanical stress, induce the cellular release of ATP and NAD

Indexed as

Adenosine5'-NucleotidaseAdenosine Diphosphate RiboseADP-RibosylationGPI-Linked ProteinsHumansMembrane ProteinsNAD5'-NucleotidaseAdenosineAdenosine Diphosphate RiboseGPI-Linked ProteinsMembrane ProteinsNADNT5E protein, humanAdenosineCD296Mono-ADP-ribosylationNT5ePost-translational modification

Identifiers

PMID34961895
PMCPMC8850506
OpenAlexW4200623044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.